Independence divergence-generated binary trees of amino acids

G. Tusnády, Gábor Tusnády, I. Simon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The discovery of the relationship between amino acids is important in terms of the replacement ability, as used in protein engineering homology studies, and gaining a better understanding of the roles which various properties of the residues play in the creation of a unique, stable, 3-D protein structure. Amino acid sequences of proteins edited by evolution are anything but random. The measure of nonrandomness, i.e. the level of editing, can be characterized by an independence divergence value. This parameter is used to generate binary tree relationships between amino acids. The relationships of residues presented in this paper are based on protein building features and not on the physico-chemical characteristics of amino acids. This approach is not biased by the tautology present in all sequence similarity-based relationship studies. The roles which various physico-chemical characteristics play in the determination of the relationships between amino acids are also discussed.

Original languageEnglish
Pages (from-to)417-423
Number of pages7
JournalProtein Engineering, Design and Selection
Volume8
Issue number5
DOIs
Publication statusPublished - May 1995

Fingerprint

Binary trees
Amino acids
Amino Acids
Proteins
Protein Engineering
Amino Acid Sequence

Keywords

  • Amino acid distance matrix
  • Homology studies
  • Protein design
  • Sequence analysis

ASJC Scopus subject areas

  • Pharmacology
  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Molecular Biology
  • Bioengineering
  • Biotechnology
  • Biochemistry

Cite this

Independence divergence-generated binary trees of amino acids. / Tusnády, G.; Tusnády, Gábor; Simon, I.

In: Protein Engineering, Design and Selection, Vol. 8, No. 5, 05.1995, p. 417-423.

Research output: Contribution to journalArticle

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