Increasing the solubility characteristics of iomeglamic acid with β-cyclodextrin

Michael Kata, Zoltán Aigner, Piroska Révész, Béla Selmeczi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Iomeglamic acid has been successfully applied for radioscopy of the gall-bladder since 1972. This pharmacon has the disadvantageous property that it is practically insoluble in water. Preparations containing the drug in different concentrations were made with β-cyclodextrin by different methods, and their dissolution characteristics were determined. In the best situation the solubility increased ten-fold. The tablets were made from the most suitable complex, with β-cyclodextrin. The conditions of tableting, the parameters and the dissolution of the tablets were tested.

Original languageEnglish
Pages (from-to)289-299
Number of pages11
JournalJournal of Inclusion Phenomena and Molecular Recognition in Chemistry
Volume7
Issue number3
DOIs
Publication statusPublished - Jun 1 1989

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Keywords

  • cyclodextrin complexation
  • increase of solubility characteristics
  • iomeglamic acid
  • tableting
  • tests on tablets
  • β-cyclodextrin

ASJC Scopus subject areas

  • Food Science
  • Chemistry(all)
  • Condensed Matter Physics

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