Increasing the solubility characteristics of fenofibrate with cyclodextrin

Zoltán Aigner, Ingrid Bencz, Michael Kata

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The incidence of genetic lipoprotein disorders, or hyperlipoproteinaemia, is currently increasing. Examinations were carried out on the hyperlipoproteinaemic drug fenofibrate and various cyclodextrin derivatives were applied to increase the solubility of this drug. Numerous products with several compositions (drug: CD mole ratio=2:1, 1:1, 1:2 or 1:3) were studied and three preparation methods (powder mixing, kneading and precipitation) were used. In vitro drug liberation and membrane diffusion examinations revealed compositions suitable for the preparation of a capsule dosage form (1:2 and 1:3 physical mixtures).

Original languageEnglish
Pages (from-to)241-252
Number of pages12
JournalJournal of Inclusion Phenomena and Molecular Recognition in Chemistry
Volume20
Issue number3
DOIs
Publication statusPublished - Sep 1994

Keywords

  • Cyclodextrins
  • DIMEB
  • fenofibrate
  • increase of solubility characteristics
  • kneading
  • membrane diffusion
  • mixing
  • precipitation

ASJC Scopus subject areas

  • Food Science
  • Chemistry(all)
  • Condensed Matter Physics

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