Increasing the solubility characteristics of fenofibrate with cyclodextrin

Z. Aigner, Ingrid Bencz, Michael Kata

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The incidence of genetic lipoprotein disorders, or hyperlipoproteinaemia, is currently increasing. Examinations were carried out on the hyperlipoproteinaemic drug fenofibrate and various cyclodextrin derivatives were applied to increase the solubility of this drug. Numerous products with several compositions (drug: CD mole ratio=2:1, 1:1, 1:2 or 1:3) were studied and three preparation methods (powder mixing, kneading and precipitation) were used. In vitro drug liberation and membrane diffusion examinations revealed compositions suitable for the preparation of a capsule dosage form (1:2 and 1:3 physical mixtures).

Original languageEnglish
Pages (from-to)241-252
Number of pages12
JournalJournal of Inclusion Phenomena and Molecular Recognition in Chemistry
Volume20
Issue number3
DOIs
Publication statusPublished - Sep 1994

Fingerprint

Fenofibrate
cyclodextrins
Cyclodextrins
Solubility
solubility
drugs
Pharmaceutical Preparations
Hyperlipoproteinemias
Inborn Genetic Diseases
examination
Dosage Forms
hyperlipoproteinemia
kneading
lipoproteins
Powders
preparation
Lipoproteins
Capsules
capsules
Chemical analysis

Keywords

  • Cyclodextrins
  • DIMEB
  • fenofibrate
  • increase of solubility characteristics
  • kneading
  • membrane diffusion
  • mixing
  • precipitation

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Chemistry(all)

Cite this

Increasing the solubility characteristics of fenofibrate with cyclodextrin. / Aigner, Z.; Bencz, Ingrid; Kata, Michael.

In: Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, Vol. 20, No. 3, 09.1994, p. 241-252.

Research output: Contribution to journalArticle

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