Increased yields of exchanges but not of deletions in X-irradiated human peripheral lymphocytes following phytohemagglutinin stimulation

S. Gundy, M. A. Bender

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We have irradiated human peripheral lymphocytes after various intervals of phytohemagglutinin stimulation to determine the time course for exchange induction and to determine whether or not deletion yields increase with increasing intervals of stimulation. We found no increase in deletion yields for intervals up to 12 hr, and rings and dicentric yields increased by about 60% in the interval between 0 and 6 hr but then reached a plateau. We also measured induced unscheduled DNA synthesis during the same interval and found it generally increased during the first 6 hr like exchange yields, but then tended to decrease again.

Original languageEnglish
Pages (from-to)519-525
Number of pages7
JournalRadiation Research
Volume97
Issue number3
Publication statusPublished - 1984

Fingerprint

deletion
lymphocytes
phytohemagglutinin
Phytohemagglutinins
stimulation
Lymphocytes
intervals
DNA
plateaus
induction
deoxyribonucleic acid
synthesis
rings

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Increased yields of exchanges but not of deletions in X-irradiated human peripheral lymphocytes following phytohemagglutinin stimulation. / Gundy, S.; Bender, M. A.

In: Radiation Research, Vol. 97, No. 3, 1984, p. 519-525.

Research output: Contribution to journalArticle

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