Increased total scavenger capacity in rats fed corticosterone and cortisol on lipid-rich diet

J. Stark, Zs Tulassay, G. Lengyel, D. Szombath, B. Székács, I. Ádler, I. Marczell, P. Nagy-Répas, E. Dinya, K. Rácz, G. Békési, Iván Horváth

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: In our earlier studies both corticosterone and cortisol had antioxidant effect in vitro. Objectives: Our aim was to clarify whether corticosterone and cortisol oral administration results in beneficial antioxidant changes in Sprague-Dawley adult male rats in vivo. Methods: Experimental animals were fed a lipid rich diet and treated with corticosterone or cortisol in the drinking fluid. Control group was fed only lipid rich diet with untreated drinking water. The untreated group was fed a normal diet with untreated water. Total scavenger capacity (TSC) was measured before and after 4 weeks of treatment in blood samples using a chemiluminometric assay. Results: Both corticosterone and cortisol treatment caused increased TSC. The control group and the untreated group showed no significant changes in TSC. Conclusion: Our results support the hypothesis that corticosterone and cortisol administration can improve the antioxidant status not only in vitro but also in vivo.

Original languageEnglish
Pages (from-to)84-88
Number of pages5
JournalActa physiologica Hungarica
Volume100
Issue number1
DOIs
Publication statusPublished - Mar 1 2013

Keywords

  • Antioxidant
  • Corticosterone
  • Cortisol
  • Free radical
  • Lipid-rich diet
  • Rats
  • Total scavenger capacity

ASJC Scopus subject areas

  • Physiology (medical)

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