Increased susceptibility to Yersinia enterocolitica infection of TFF2 deficient mice

Aftab A. Shah, Martina Mihalj, Ivana Ratkay, Maria Lubka-Pathak, P. Balogh, Karin Klingel, Erwin Bohn, Nikolaus Blin, Mirela Baus-Loncar

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

TFF2 is one of the members of the trefoil factor family, known for its role in protection of gastrointestinal epithelia upon injury; however, recent studies suggest that TFF2 could also play an important role in the immune system. In the present study Tff2 deficient and wild type mice were infected by Y. enterocolitica which resulted in a lethal outcome in all Tff2 deficient mice, but not in WT animals. Yersinia invaded Peyer's patches more efficiently as shown by high bacterial titers in the KO mice while wild type mice displayed lower titers and a visible bacterial accumulation in the intestine. Bacterial accumulation in Peyer's patches of Tff2 deficient mice was accompanied by increased recruitment of macrophages. While an increased level of MAC-1. positive cells was observed in the spleens of both Tff2 deficient and WT mice at third day post infection, bacterial dissemination to liver, lung and kidneys was observed only in Tff2 knock-out mice. Analysis of the cellular composition of spleen did not reveal any substantial alteration to WT animals, suggesting possible disregulation of hemopoietic cells involved in immune response to Y. enterocolitica. These new data indicate that Tff2 plays an important role in immune response by protecting the organism from consequences of infection and that Tff2 knock-out mice react adversely to bacterial infections, in this case specifically to Y. enterocolitica.

Original languageEnglish
Pages (from-to)853-862
Number of pages10
JournalCellular Physiology and Biochemistry
Volume30
Issue number4
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Yersinia Infections
Yersinia enterocolitica
Peyer's Patches
Bacterial Infections
Knockout Mice
Spleen
Yersinia
Intestines
Immune System
Epithelium
Macrophages
Kidney
Lung
Liver
Wounds and Injuries
Infection

Keywords

  • Cytoprotective peptides
  • Gastrointestinal tract
  • Trefoil factor family
  • Yersinia infections

ASJC Scopus subject areas

  • Physiology

Cite this

Shah, A. A., Mihalj, M., Ratkay, I., Lubka-Pathak, M., Balogh, P., Klingel, K., ... Baus-Loncar, M. (2012). Increased susceptibility to Yersinia enterocolitica infection of TFF2 deficient mice. Cellular Physiology and Biochemistry, 30(4), 853-862. https://doi.org/10.1159/000341463

Increased susceptibility to Yersinia enterocolitica infection of TFF2 deficient mice. / Shah, Aftab A.; Mihalj, Martina; Ratkay, Ivana; Lubka-Pathak, Maria; Balogh, P.; Klingel, Karin; Bohn, Erwin; Blin, Nikolaus; Baus-Loncar, Mirela.

In: Cellular Physiology and Biochemistry, Vol. 30, No. 4, 09.2012, p. 853-862.

Research output: Contribution to journalArticle

Shah, AA, Mihalj, M, Ratkay, I, Lubka-Pathak, M, Balogh, P, Klingel, K, Bohn, E, Blin, N & Baus-Loncar, M 2012, 'Increased susceptibility to Yersinia enterocolitica infection of TFF2 deficient mice', Cellular Physiology and Biochemistry, vol. 30, no. 4, pp. 853-862. https://doi.org/10.1159/000341463
Shah, Aftab A. ; Mihalj, Martina ; Ratkay, Ivana ; Lubka-Pathak, Maria ; Balogh, P. ; Klingel, Karin ; Bohn, Erwin ; Blin, Nikolaus ; Baus-Loncar, Mirela. / Increased susceptibility to Yersinia enterocolitica infection of TFF2 deficient mice. In: Cellular Physiology and Biochemistry. 2012 ; Vol. 30, No. 4. pp. 853-862.
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