Increased short-term beat-to-beat QT interval variability in patients with impaired glucose tolerance

Andrea Orosz, István Baczkó, Szabolcs Nyiraty, Anna E. Körei, Zsuzsanna Putz, Róbert Takács, Attila Nemes, Tamás T. Várkonyi, László Balogh, György Ábrahám, P. Kempler, Julius Gy Papp, András Varró, Csaba Lengyel

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Prediabetic states and diabetes are important risk factors for cardiovascular morbidity and mortality. Determination of short-term QT interval variability (STVQT) is a non-invasive method for assessment of proarrhythmic risk. The aim of the study was to evaluate the STVQT in patients with impaired glucose tolerance (IGT). 18 IGT patients [age: 63 ± 11 years, body mass index (BMI): 31 ± 6 kg/m2, fasting glucose: 6.0 ± 0.4 mmol/l, 120 min postload glucose: 9.0 ± 1.0 mmol/l, hemoglobin A1c (HbA1c): 5.9 ± 0.4%; mean ± SD] and 18 healthy controls (age: 56 ± 9 years, BMI: 27 ± 5 kg/m2, fasting glucose: 5.2 ± 0.4 mmol/l, 120 min postload glucose: 5.5 ± 1.3 mmol/l, HbA1c: 5.4 ± 0.3%) were enrolled into the study. ECGs were recorded, processed, and analyzed off-line. The RR and QT intervals were expressed as the average of 30 consecutive beats, the temporal instability of beat-to-beat repolarization was characterized by calculating STVQT as follows: STVQT = Σ|QTn + 1 - QTn| (30x√2)-1. Autonomic function was assessed by means of standard cardiovascular reflex tests. There were no differences between IGT and control groups in QT (411 ± 43 vs 402 ± 39 ms) and QTc (431 ± 25 vs 424 ± 19 ms) intervals or QT dispersion (44 ± 13 vs 42 ± 17 ms). However, STVQT was significantly higher in IGT patients (5.0 ± 0.7 vs 3.7 ± 0.7, P < 0.0001). The elevated temporal STVQT in patients with IGT may be an early indicator of increased instability of cardiac repolarization during prediabetic conditions.

Original languageEnglish
Article number129
JournalFrontiers in Endocrinology
Volume8
Issue numberJUN
DOIs
Publication statusPublished - Jun 13 2017

Keywords

  • Cardiovascular autonomic neuropathy
  • Impaired glucose tolerance
  • Prediabetes
  • Proarrhythmic risk
  • QT dispersion
  • QT prolongation
  • Short-term variability of the QT interval
  • Sudden cardiac death

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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