Increased serum butyrylcholinesterase activity in type IIb hyperlipidaemic patients

J. Kálmán, A. Juhász, Zoltán Rakonczay, György Ábrahám, Marianna Zana, K. Boda, T. Farkas, B. Penke, Z. Janka

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The inheritance of the apolipoprotein E4 (APOE4) allele has been shown to increase the plasma cholesterol level, but little information is as concerns the association of the APOE genotype and hyperlipidaemia and the activities of two serum enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Blood samples from 55 type IIb hyperlipidaemic, non-demented patients and 55 age- and sex-matched controls were therefore examined in this pilot study. A significantly increased BChE activity was found in the serum of type IIb hyperlipidaemic patients, but the AChE activity did not differ significantly as compared with that in the control group. The APOE4 allele was significantly overrepresented among the hyperlipidaemic probands, but neither serum cholinesterase activity was affected by the dosage of the APOE4 gene. Our results point to a possible association between an abnormal lipid metabolism and the BChE activity and might have implications as regards the pathomechanism of both Alzheimer's and vascular dementias and the cholinesterase inhibitor therapy of dementing disorders.

Original languageEnglish
Pages (from-to)1195-1204
Number of pages10
JournalLife Sciences
Volume75
Issue number10
DOIs
Publication statusPublished - Jul 23 2004

Fingerprint

Apolipoprotein E4
Butyrylcholinesterase
Acetylcholinesterase
Serum
Alleles
Vascular Dementia
Cholinesterase Inhibitors
Cholinesterases
Hyperlipidemias
Lipid Metabolism
Alzheimer Disease
Blood
Genes
Cholesterol
Genotype
Plasmas
Control Groups
Enzymes
Therapeutics

Keywords

  • Acetylcholinesterase
  • Apolipoprotein E
  • Butyrylcholinesterase
  • Cholesterol
  • Hyperlipidaemia
  • Serum
  • Triglyceride

ASJC Scopus subject areas

  • Pharmacology

Cite this

Increased serum butyrylcholinesterase activity in type IIb hyperlipidaemic patients. / Kálmán, J.; Juhász, A.; Rakonczay, Zoltán; Ábrahám, György; Zana, Marianna; Boda, K.; Farkas, T.; Penke, B.; Janka, Z.

In: Life Sciences, Vol. 75, No. 10, 23.07.2004, p. 1195-1204.

Research output: Contribution to journalArticle

@article{a5b8483be4e54500b8845cd7764b6442,
title = "Increased serum butyrylcholinesterase activity in type IIb hyperlipidaemic patients",
abstract = "The inheritance of the apolipoprotein E4 (APOE4) allele has been shown to increase the plasma cholesterol level, but little information is as concerns the association of the APOE genotype and hyperlipidaemia and the activities of two serum enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Blood samples from 55 type IIb hyperlipidaemic, non-demented patients and 55 age- and sex-matched controls were therefore examined in this pilot study. A significantly increased BChE activity was found in the serum of type IIb hyperlipidaemic patients, but the AChE activity did not differ significantly as compared with that in the control group. The APOE4 allele was significantly overrepresented among the hyperlipidaemic probands, but neither serum cholinesterase activity was affected by the dosage of the APOE4 gene. Our results point to a possible association between an abnormal lipid metabolism and the BChE activity and might have implications as regards the pathomechanism of both Alzheimer's and vascular dementias and the cholinesterase inhibitor therapy of dementing disorders.",
keywords = "Acetylcholinesterase, Apolipoprotein E, Butyrylcholinesterase, Cholesterol, Hyperlipidaemia, Serum, Triglyceride",
author = "J. K{\'a}lm{\'a}n and A. Juh{\'a}sz and Zolt{\'a}n Rakonczay and Gy{\"o}rgy {\'A}brah{\'a}m and Marianna Zana and K. Boda and T. Farkas and B. Penke and Z. Janka",
year = "2004",
month = "7",
day = "23",
doi = "10.1016/j.lfs.2004.02.019",
language = "English",
volume = "75",
pages = "1195--1204",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "10",

}

TY - JOUR

T1 - Increased serum butyrylcholinesterase activity in type IIb hyperlipidaemic patients

AU - Kálmán, J.

AU - Juhász, A.

AU - Rakonczay, Zoltán

AU - Ábrahám, György

AU - Zana, Marianna

AU - Boda, K.

AU - Farkas, T.

AU - Penke, B.

AU - Janka, Z.

PY - 2004/7/23

Y1 - 2004/7/23

N2 - The inheritance of the apolipoprotein E4 (APOE4) allele has been shown to increase the plasma cholesterol level, but little information is as concerns the association of the APOE genotype and hyperlipidaemia and the activities of two serum enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Blood samples from 55 type IIb hyperlipidaemic, non-demented patients and 55 age- and sex-matched controls were therefore examined in this pilot study. A significantly increased BChE activity was found in the serum of type IIb hyperlipidaemic patients, but the AChE activity did not differ significantly as compared with that in the control group. The APOE4 allele was significantly overrepresented among the hyperlipidaemic probands, but neither serum cholinesterase activity was affected by the dosage of the APOE4 gene. Our results point to a possible association between an abnormal lipid metabolism and the BChE activity and might have implications as regards the pathomechanism of both Alzheimer's and vascular dementias and the cholinesterase inhibitor therapy of dementing disorders.

AB - The inheritance of the apolipoprotein E4 (APOE4) allele has been shown to increase the plasma cholesterol level, but little information is as concerns the association of the APOE genotype and hyperlipidaemia and the activities of two serum enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Blood samples from 55 type IIb hyperlipidaemic, non-demented patients and 55 age- and sex-matched controls were therefore examined in this pilot study. A significantly increased BChE activity was found in the serum of type IIb hyperlipidaemic patients, but the AChE activity did not differ significantly as compared with that in the control group. The APOE4 allele was significantly overrepresented among the hyperlipidaemic probands, but neither serum cholinesterase activity was affected by the dosage of the APOE4 gene. Our results point to a possible association between an abnormal lipid metabolism and the BChE activity and might have implications as regards the pathomechanism of both Alzheimer's and vascular dementias and the cholinesterase inhibitor therapy of dementing disorders.

KW - Acetylcholinesterase

KW - Apolipoprotein E

KW - Butyrylcholinesterase

KW - Cholesterol

KW - Hyperlipidaemia

KW - Serum

KW - Triglyceride

UR - http://www.scopus.com/inward/record.url?scp=3042643044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042643044&partnerID=8YFLogxK

U2 - 10.1016/j.lfs.2004.02.019

DO - 10.1016/j.lfs.2004.02.019

M3 - Article

VL - 75

SP - 1195

EP - 1204

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 10

ER -