Increased serum butyrylcholinesterase activity in type IIb hyperlipidaemic patients

János Kálmán, Anna Juhász, Zoltán Rakonczay, György Ábrahám, Marianna Zana, Krisztina Boda, Tibor Farkas, Botond Penke, Zoltán Janka

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The inheritance of the apolipoprotein E4 (APOE4) allele has been shown to increase the plasma cholesterol level, but little information is as concerns the association of the APOE genotype and hyperlipidaemia and the activities of two serum enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Blood samples from 55 type IIb hyperlipidaemic, non-demented patients and 55 age- and sex-matched controls were therefore examined in this pilot study. A significantly increased BChE activity was found in the serum of type IIb hyperlipidaemic patients, but the AChE activity did not differ significantly as compared with that in the control group. The APOE4 allele was significantly overrepresented among the hyperlipidaemic probands, but neither serum cholinesterase activity was affected by the dosage of the APOE4 gene. Our results point to a possible association between an abnormal lipid metabolism and the BChE activity and might have implications as regards the pathomechanism of both Alzheimer's and vascular dementias and the cholinesterase inhibitor therapy of dementing disorders.

Original languageEnglish
Pages (from-to)1195-1204
Number of pages10
JournalLife Sciences
Volume75
Issue number10
DOIs
Publication statusPublished - Jul 23 2004

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Keywords

  • Acetylcholinesterase
  • Apolipoprotein E
  • Butyrylcholinesterase
  • Cholesterol
  • Hyperlipidaemia
  • Serum
  • Triglyceride

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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