Increased serum adenosine and interleukin 10 levels as new laboratory markers of increased intra-abdominal pressure

Zsolt Bodnár, Tamás Keresztes, Ildikó Kovács, Zoltán Hajdu, Gilbert A. Boissonneault, S. Sipka

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Increased intra-abdominal pressure (IAP), intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are severe complications of surgical interventions with a high rate of mortality. The technique of IAP measurement is accurate, precise, reproducible and cost-effective. However, laboratory measures for monitoring of IAH have not been defined. We investigated the linkage between the serum levels of adenosine and interleukin 10 (IL-10) with IAP. Methods: The sera of 25 surgical patients with IAP 12 mmHg were tested. Serum adenosine concentration was measured by HPLC. Serum IL-1β, IL-2, IL-4, IL-10, TNFα, IFNγ and IL-10 were determined by enzyme linked immunosorbent assay (ELISA). CRP was measured by nephelometry. Results: Significant correlations of IAP were found only with serum levels of adenosine and IL-10. In the sera of patients with IAP >12 mmHg, the levels of both adenosine (1.61 versus 0.06 μM, p <0.01) and IL-10 (63.23 versus 27.27 pg/ml, p <0.01) were significantly higher than those in patients with IAP 15 (Grade II-IV). Conclusion: We report associations between IAP and the serum adenosine and IL-10 levels providing new tools for the laboratory monitoring of IAH as well as further understanding of the pathomechanisms contributing to ACS.

Original languageEnglish
Pages (from-to)969-972
Number of pages4
JournalLangenbeck's Archives of Surgery
Volume395
Issue number7
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Interleukin-10
Adenosine
Intra-Abdominal Hypertension
Biomarkers
Pressure
Serum
Nephelometry and Turbidimetry
Interleukin-1
Interleukin-4
Interleukin-2
Enzyme-Linked Immunosorbent Assay
High Pressure Liquid Chromatography
Costs and Cost Analysis
Mortality

Keywords

  • Adenosine
  • Interleukin 10
  • Intra-abdominal pressure (IAP)

ASJC Scopus subject areas

  • Surgery

Cite this

Increased serum adenosine and interleukin 10 levels as new laboratory markers of increased intra-abdominal pressure. / Bodnár, Zsolt; Keresztes, Tamás; Kovács, Ildikó; Hajdu, Zoltán; Boissonneault, Gilbert A.; Sipka, S.

In: Langenbeck's Archives of Surgery, Vol. 395, No. 7, 09.2010, p. 969-972.

Research output: Contribution to journalArticle

Bodnár, Zsolt ; Keresztes, Tamás ; Kovács, Ildikó ; Hajdu, Zoltán ; Boissonneault, Gilbert A. ; Sipka, S. / Increased serum adenosine and interleukin 10 levels as new laboratory markers of increased intra-abdominal pressure. In: Langenbeck's Archives of Surgery. 2010 ; Vol. 395, No. 7. pp. 969-972.
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