Increased sensitivity to picrotoxin as an index of physical dependence on alcohol in the mouse

Gyula Szabó, G. Kovács, G. Telegdy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A relatively simple and rapid method has been developed to induce tolerance to and dependence on alcohol in mice. Alternating intraperitoneal injections of metabolically stable tert-butanol and ethanol for 4 consecutive days resulted in a physical dependence on alcohol, which was quantified by the latency and ED50 of picrotoxin-induced CNS hyperexcitability - myoclonic and tonic seizures and mortality - during the withdrawal period. The data indicate that alcohol-dependent animals in the withdrawal period are more susceptible than alcohol-naive controls to picrotoxin. Withdrawal hyperexcitability can be quantified by the ED50 of picrotoxin.

Original languageEnglish
Pages (from-to)187-195
Number of pages9
JournalDrug and Alcohol Dependence
Volume14
Issue number2
DOIs
Publication statusPublished - 1984

Fingerprint

Picrotoxin
Alcoholism
alcohol
Alcohols
withdrawal
tert-Butyl Alcohol
Intraperitoneal Injections
seizure
Seizures
Ethanol
tolerance
Animals
mortality
Mortality
animal

Keywords

  • Convulsion
  • Dependence
  • Ethanol
  • Picrotoxin
  • tert-Butanol
  • Tolerance

ASJC Scopus subject areas

  • Medicine(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

Cite this

Increased sensitivity to picrotoxin as an index of physical dependence on alcohol in the mouse. / Szabó, Gyula; Kovács, G.; Telegdy, G.

In: Drug and Alcohol Dependence, Vol. 14, No. 2, 1984, p. 187-195.

Research output: Contribution to journalArticle

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