Increased SCE inducibility by low doses of methylcholanthrene in lymphocytes obtained from patients with Down's disease

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Abstract

The inducibility of sister-chromatid exchanges (SCEs) following 3-methylcholanthrene (MC) treatment of normal human peripheral blood lymphocytes and of in vitro cultured normal human embryo fibroblasts, as well as peripheral blood lymphocytes of patients with Down's disease and of fibroblasts of an embryo with trisomy 21 has been investigated. 10-6 M MC treatment increased the frequency of SCEs by 2.5 in the case of Down lymphocytes when compared to the healthy control. The fibroblasts with trisomy 21, however, did not show an increased sensitivity to MC treatment when compared with normal fibroblasts, expressed in the number of SCEs per nucleus found in the cells.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume149
Issue number1
DOIs
Publication statusPublished - 1985

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Sister Chromatid Exchange
Methylcholanthrene
Fibroblasts
Lymphocytes
Down Syndrome
Embryonic Structures
Therapeutics

ASJC Scopus subject areas

  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

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title = "Increased SCE inducibility by low doses of methylcholanthrene in lymphocytes obtained from patients with Down's disease",
abstract = "The inducibility of sister-chromatid exchanges (SCEs) following 3-methylcholanthrene (MC) treatment of normal human peripheral blood lymphocytes and of in vitro cultured normal human embryo fibroblasts, as well as peripheral blood lymphocytes of patients with Down's disease and of fibroblasts of an embryo with trisomy 21 has been investigated. 10-6 M MC treatment increased the frequency of SCEs by 2.5 in the case of Down lymphocytes when compared to the healthy control. The fibroblasts with trisomy 21, however, did not show an increased sensitivity to MC treatment when compared with normal fibroblasts, expressed in the number of SCEs per nucleus found in the cells.",
author = "J. Major and B. Szende and K. Lapis and Zs Th{\'e}sz",
year = "1985",
doi = "10.1016/0027-5107(85)90008-9",
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T1 - Increased SCE inducibility by low doses of methylcholanthrene in lymphocytes obtained from patients with Down's disease

AU - Major, J.

AU - Szende, B.

AU - Lapis, K.

AU - Thész, Zs

PY - 1985

Y1 - 1985

N2 - The inducibility of sister-chromatid exchanges (SCEs) following 3-methylcholanthrene (MC) treatment of normal human peripheral blood lymphocytes and of in vitro cultured normal human embryo fibroblasts, as well as peripheral blood lymphocytes of patients with Down's disease and of fibroblasts of an embryo with trisomy 21 has been investigated. 10-6 M MC treatment increased the frequency of SCEs by 2.5 in the case of Down lymphocytes when compared to the healthy control. The fibroblasts with trisomy 21, however, did not show an increased sensitivity to MC treatment when compared with normal fibroblasts, expressed in the number of SCEs per nucleus found in the cells.

AB - The inducibility of sister-chromatid exchanges (SCEs) following 3-methylcholanthrene (MC) treatment of normal human peripheral blood lymphocytes and of in vitro cultured normal human embryo fibroblasts, as well as peripheral blood lymphocytes of patients with Down's disease and of fibroblasts of an embryo with trisomy 21 has been investigated. 10-6 M MC treatment increased the frequency of SCEs by 2.5 in the case of Down lymphocytes when compared to the healthy control. The fibroblasts with trisomy 21, however, did not show an increased sensitivity to MC treatment when compared with normal fibroblasts, expressed in the number of SCEs per nucleus found in the cells.

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U2 - 10.1016/0027-5107(85)90008-9

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SP - 51

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JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

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