Increased prevalence of IL-17-producing peripheral blood lymphocytes in pre-eclampsia.

Gergely Toldi, J. Rigó, Balázs Stenczer, B. Vásárhelyi, A. Molvarec

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Abstract

Systemic inflammation is a dominant component in the pathogenesis of pre-eclampsia. Besides the imbalance of Th1 and Th2 cells, alterations of the prevalence of Th17 and regulatory T cells have also been suggested to contribute to inflammation. We aimed to describe the prevalence of these four CD4 lymphocyte subtypes in pre-eclampsia and normal pregnancy, along with that of IL-17-producing CD8 and NK cells. Twenty pre-eclamptic and 22 normal pregnant women were enrolled in this study. Using flow cytometry, we determined the prevalence of IL-17-producing cells among the CD4, CD8 and NK cell subsets. Furthermore, we measured the prevalence of CD4+ Tregs, and Th1/Th2 cells were characterized using cell surface chemokine receptor markers. We demonstrated that there is a shift not only in the Th1/Th2 but also in the Th17/Treg balance favouring skewness towards a pro-inflammatory status in pre-eclampsia. The proportion of CD8 and NK cells that express IL-17 was also higher in pre-eclampsia. The prevalence of IL-17-producing CD4, CD8 and NK cells is elevated in pre-eclampsia, indicating that both the innate and adaptive arms of the immune system are involved in the development of the exaggerated maternal systemic inflammation observed in this pregnancy-specific disorder.

Original languageEnglish
Pages (from-to)223-229
Number of pages7
JournalAmerican Journal of Reproductive Immunology
Volume66
Issue number3
Publication statusPublished - Sep 2011

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Interleukin-17
Pre-Eclampsia
Natural Killer Cells
Lymphocytes
Th2 Cells
Th1 Cells
Inflammation
Pregnancy
Chemokine Receptors
Cell Surface Receptors
Regulatory T-Lymphocytes
Pregnant Women
Immune System
Flow Cytometry
Mothers

ASJC Scopus subject areas

  • Medicine(all)

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Increased prevalence of IL-17-producing peripheral blood lymphocytes in pre-eclampsia. / Toldi, Gergely; Rigó, J.; Stenczer, Balázs; Vásárhelyi, B.; Molvarec, A.

In: American Journal of Reproductive Immunology, Vol. 66, No. 3, 09.2011, p. 223-229.

Research output: Contribution to journalArticle

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