Increased preoperative glucose levels are associated with perioperative mortality in patients undergoing noncardiac, nonvascular surgery

Peter G. Noordzij, Eric Boersma, Frodo Schereiner, M. Kertai, Harm H H Feringa, Martin Dunkelgrun, Jeroen J. Bax, Jan Klein, Don Poldermans

Research output: Contribution to journalArticle

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Abstract

Objective: To determine the relationship between preoperative glucose levels and perioperative mortality in noncardiac, nonvascular surgery. Research design and methods: We performed a case-control study in a cohort of 108 593 patients who underwent noncardiac surgery at the Erasmus MC during 1991-2001. Cases were 989 patients who underwent elective noncardiac, nonvascular surgery and died within 30 days during hospital stay. From the remaining patients, 1879 matched controls (age, sex, calendar year, and type of surgery) were selected. Information was obtained regarding the presence of cardiac risk factors, medication, and preoperative laboratory results. Preoperative random glucose levels <5.6 mmol/l (110 mg/dl) were normal. Impaired glucose levels in the range of 5.6-11.1 mmol/l were prediabetes. Glucose levels ≥ 11.1 mmol/l (200 mg/dl) were diabetes. Results: Preoperative glucose levels were available in 904 cases and 1247 controls. A cardiovascular complication was the primary cause of death in 207 (23%) cases. Prediabetes glucose levels were associated with a 1.7-fold increased mortality risk compared with normoglycernic levels (adjusted odds ratio (OR) 1.7 and 95% confidence interval (CI) 1.4-2.1; P

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalEuropean Journal of Endocrinology
Volume156
Issue number1
DOIs
Publication statusPublished - Jan 2007

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Glucose
Mortality
Prediabetic State
Case-Control Studies
Cause of Death
Length of Stay
Research Design
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Endocrinology

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Increased preoperative glucose levels are associated with perioperative mortality in patients undergoing noncardiac, nonvascular surgery. / Noordzij, Peter G.; Boersma, Eric; Schereiner, Frodo; Kertai, M.; Feringa, Harm H H; Dunkelgrun, Martin; Bax, Jeroen J.; Klein, Jan; Poldermans, Don.

In: European Journal of Endocrinology, Vol. 156, No. 1, 01.2007, p. 137-142.

Research output: Contribution to journalArticle

Noordzij, PG, Boersma, E, Schereiner, F, Kertai, M, Feringa, HHH, Dunkelgrun, M, Bax, JJ, Klein, J & Poldermans, D 2007, 'Increased preoperative glucose levels are associated with perioperative mortality in patients undergoing noncardiac, nonvascular surgery', European Journal of Endocrinology, vol. 156, no. 1, pp. 137-142. https://doi.org/10.1530/eje.1.02321
Noordzij, Peter G. ; Boersma, Eric ; Schereiner, Frodo ; Kertai, M. ; Feringa, Harm H H ; Dunkelgrun, Martin ; Bax, Jeroen J. ; Klein, Jan ; Poldermans, Don. / Increased preoperative glucose levels are associated with perioperative mortality in patients undergoing noncardiac, nonvascular surgery. In: European Journal of Endocrinology. 2007 ; Vol. 156, No. 1. pp. 137-142.
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