Increased platelet activation and decreased fibrinolysis in the pathogenesis of aseptic necrosis of the femoral head

E. Pósán, J. Hársfalvi, K. Szepesi, L. Gáspár, P. Batár, M. Udvardy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Thrombotic events, increased tendency toward intravascular thrombosis and decreased fibrinolysis seem to be possible pathologic causes for aseptic necrosis of the femoral head (ANFH) in adults. This project was to study whether either increased platelet activation or decreased fibrinolytic activity and/or any other thrombogenic factor may be implicated in the evolvement of ANFH. The speed of the in vitro lysis was significantly lower in patients (both in primary and in secondary cases) compared with healthy controls. The platelet activation (measuring with βTG) proved to be significantly higher in the primary group as well as in the secondary group compared with healthy controls. Lp(a) levels were elevated in primary and secondary cases. This alteration was more characteristic in the primary cases. Fibrinogen levels were also elevated in the primary group, but the difference was not significant. The data shown here may further support that hypofibrinolysis and increased thrombogenesis are major causes of ANFH. Early diagnosis of ANFH increases the chances of modifying the course of this disabling disease.

Original languageEnglish
Pages (from-to)233-235
Number of pages3
JournalPlatelets
Volume9
Issue number3-4
DOIs
Publication statusPublished - 1998

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Platelet Activation
Fibrinolysis
Thigh
Necrosis
Fibrinogen
Early Diagnosis
Thrombosis

ASJC Scopus subject areas

  • Hematology
  • Cell Biology

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Increased platelet activation and decreased fibrinolysis in the pathogenesis of aseptic necrosis of the femoral head. / Pósán, E.; Hársfalvi, J.; Szepesi, K.; Gáspár, L.; Batár, P.; Udvardy, M.

In: Platelets, Vol. 9, No. 3-4, 1998, p. 233-235.

Research output: Contribution to journalArticle

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AU - Hársfalvi, J.

AU - Szepesi, K.

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AU - Batár, P.

AU - Udvardy, M.

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