Increased plasma soluble urokinase plasminogen activator receptor levels in systemic sclerosis: Possible association with microvascular abnormalities and extent of fibrosis

Nóra Legány, Gergely Toldi, Jörg H.W. Distler, Christian Beyer, Balázs Szalay, László Kovács, Barna Vásárhelyi, Attila Balog

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Urokinase plasminogen activator receptor (uPAR) is a key component of the fibrinolytic system involved in extracellular matrix remodeling and angiogenesis. Novel animal models supported the key role of uPAR not only in fibrosis but also in systemic sclerosis (SSc)-related microvascular abnormalities. The aim of this study was to investigate plasma soluble uPAR (suPAR) levels in SSc, and their association with organ-specific involvement. Methods: suPAR concentrations were measured by ELISA in SSc patient (n=83) and in healthy controls (n=29). Simultaneously, CRP and ESR were assessed. Detailed clinical data including skin, lung, heart and microvascular characteristics were evaluated at sampling. Results: suPAR values were higher in SSc patients than in controls. Subgroup analysis showed higher suPAR values in diffuse cutaneous- than in limited cutaneous SSc and correlated with anti-Scl-70+. suPAR levels also associated with pulmonary function test parameters of fibrosis, presence of microvascular lesions (e.g., Raynaud phenomenon, naifold capillaroscopic abnormalities and digital ulcers) and arthritis. Conclusions: Our data indicate that suPAR might be a valuable early diagnostic marker of SSc which also correlates with disease severity.

Original languageEnglish
Pages (from-to)1799-1805
Number of pages7
JournalClinical Chemistry and Laboratory Medicine
Volume53
Issue number11
DOIs
Publication statusPublished - Oct 1 2015

Keywords

  • fibrosis
  • microvascular abnormalities
  • pulmonary fibrosis
  • soluble urokinase plasminogen activator receptor
  • systemic sclerosis

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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