Increased oxidative stress tolerance results in general stress tolerance in Candida albicans independently of stress-elicited morphological transitions

Ágnes Jakab, Károly Antal, Ágnes Kiss, Tamás Emri, István Pócsi

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A selection of tert-butylhydroperoxide (tBOOH)-tolerant Candida albicans mutants showed increased tolerances to 19 different stress conditions. These mutants are characterized by a constitutively upregulated antioxidative defense system and, therefore, adaptation to oxidative stress may play an important role in gaining general stress tolerance in C. albicans. Although C. albicans cells may undergo morphological transitions under various stress treatments, this ability shows considerable stress-specific and strain-specific variability and, hence, it is independent of mounting stress cross protections.

Original languageEnglish
Pages (from-to)333-340
Number of pages8
JournalFolia Microbiologica
Issue number4
Publication statusPublished - Jul 2014


ASJC Scopus subject areas

  • Microbiology

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