Increased nuchal translucency and congenital heart defects in euploid fetusesThe Szeged experience

H. Orvos, Kornélia Wayda, Zoltán Kozinszky, M. Katona, A. Pál, János Szabó

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objective: To determine the utility of the first-trimester fetal nuchal translucency (NT) thickness in the prediction of fetal cardiac malformations. Design: Retrospective study. Setting: Department of Obstetrics and Gynecology and Medical Genetics, University of Szeged. Methods: The pre- and postnatal course and outcome, and the relationship between the first-trimester fetal NT thickness and fetal congenital heart defects (CHDs) in 4309 pregnancies ended up with birth or therapeutic abortion between January 1998 and June 2000 were registered. Prenatal care included first- and second-trimester fetal sonography at weeks 10-13 and 18-20, respectively. Results: 4251 births and 58 first- and second-trimester therapeutic abortions due to lethal congenital malformations or chromosomal abnormalities were recorded. Altogether 209 (4.9%) congenital malformations were detected, 39 (18.7%) of which were heart defects with normal karyotype. At birth, 151 congenital malformations were diagnosed, 34 of them were known prenatally. The prevalence of CHDs was 9 per 1000 pregnancies. The measurement of fetal NT thickness was available in 35 of the 39 fetuses with heart defects: it was ≥3mm in 18 (51.4%) and

Original languageEnglish
Pages (from-to)124-128
Number of pages5
JournalEuropean Journal of Obstetrics Gynecology and Reproductive Biology
Volume101
Issue number2
DOIs
Publication statusPublished - Mar 10 2002

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Nuchal Translucency Measurement
Congenital Heart Defects
First Pregnancy Trimester
Therapeutic Abortion
Parturition
Second Pregnancy Trimester
Prenatal Ultrasonography
Fetal Heart
Pregnancy
Hospital Obstetrics and Gynecology Department
Prenatal Care
Medical Genetics
Gynecology
Karyotype
Chromosome Aberrations
Fetus
Retrospective Studies

Keywords

  • Congenital heart defects
  • First-trimester screening
  • Nuchal translucency

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Increased nuchal translucency and congenital heart defects in euploid fetusesThe Szeged experience. / Orvos, H.; Wayda, Kornélia; Kozinszky, Zoltán; Katona, M.; Pál, A.; Szabó, János.

In: European Journal of Obstetrics Gynecology and Reproductive Biology, Vol. 101, No. 2, 10.03.2002, p. 124-128.

Research output: Contribution to journalArticle

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