Increased nitric oxide levels as an early sign of premature aging in diabetes

Krisztián Stadler, Veronika Jenei, Gábor Von Bölcsházy, Anikó Somogyi, Judit Jakus

Research output: Contribution to journalArticle

89 Citations (Scopus)


The levels of different reactive species, especially those of nitric oxide and peroxynitrite, were determined in streptozotocin-induced diabetic rat tissues, before the development of histopathological damages. Significantly higher steady state free radical concentrations were found in the liver 3 weeks after the onset of diabetes compared to age-matched control groups. Increased nitric oxide levels in diabetic vasculature and kidney decreased the production of detectable reactive oxygen species. High peroxynitrite generation suggested the onset of processes characteristic to premature aging of the endothelium. According to the histopathological results, there were no signs of late complications in the tissues up to 7 weeks after induction of diabetes. These results support the idea that oxidative stress is increased at a very early stage of diabetes and, in particular, that high levels of nitric oxide and peroxynitrite could play a decisive role in the development of late complications in the diabetic vasculature and kidney.

Original languageEnglish
Pages (from-to)1240-1251
Number of pages12
JournalFree Radical Biology and Medicine
Issue number10
Publication statusPublished - Nov 15 2003


  • Diabetes mellitus
  • EPR spectroscopy
  • Free radicals
  • Late complications
  • Nitric oxide
  • Peroxynitrite
  • Reactive oxygen species
  • Spin trapping

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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