Increased monophasic action potential dispersion in endothelin-1-induced ventricular arrhythmias

László Gellér, Béla Merkely, Volker Lang, Tamás Szabó, Levante Fazekas, Violetta Kékesi, Orsolya Kiss, Ferenc Horkay, Max Schaldach, Miklós Tóth, Alexander Juhász-Nagy

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The aim of this study was to investigate the changes in monophasic action potentials (MAP) from different sites in the heart and to determine MAP dispersion during endothelin-1 (ET-1) infusion. Standard ECG, left ventricular anterior, right ventricular lateral, right ventricular septal, and right ventricular apical MAPs and intra-arterial blood pressure were monitored in seven anesthetized open-chest mongrel dogs. After radiofrequency atrioventricular node ablation, ventricular pacing (70/min) was performed and intracoronary ET-1 (60 pmol/min) was administered into the left anterior descending coronary artery. Both MAPd90 and MAPd90 dispersion increased significant during ET-1 infusion. The onset of spontaneous monomorphic and polymorphic sustained ventricular tachycardias (sVT) was observed in five dogs (around 40 min), and nonsustained VTs (nsVT) developed in another two dogs. The increases in MAP and MAP dispersion lasted until the appearance of polymorphic nsVTs and sVTs, but at the time of these VTs this difference decreased. At the termination of the experiments, ventricular fibrillation occurred in six cases. In four cases third-phase early afterdepolarizations were recorded. Our results suggest that increased MAP dispersion and development of EAD contribute to the arrhythmogenic action of ET-1, and these phenomena might explain the pathogenesis of a wide variety of ventricular arrhythmias with different mor-phology observed in this study.

Original languageEnglish
Pages (from-to)S434-S436
JournalJournal of cardiovascular pharmacology
Volume31
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jan 1 1998

Keywords

  • Endothelin
  • Monophasic action potential dispersion
  • Ventricular arrhythmia

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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