Increased lysosomal fragility in the human uterine cervix following estrogen therapy

J. Herczeg, A. Borsodi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In vitro stability of the lysosomal membrane complex was studied in non-pregnant human uterine cervices. The oestrogen therapy caused markedly enhanced lability of the lysosomal membrane complex as evidenced by higher activity of the "marker" enzyme when the preparations were challenged by mechanical or detergent stress. Oestradiol-17β might be implicated in altering the metabolism of the proteoglycan complex which may result in the "ripening" of the pregnant cervix.

Original languageEnglish
Pages (from-to)131-133
Number of pages3
JournalArchives of Gynecology
Volume236
Issue number3
DOIs
Publication statusPublished - Apr 1985

Fingerprint

Cervix Uteri
Estrogens
Membranes
Proteoglycans
Detergents
Estradiol
Enzymes
Therapeutics
In Vitro Techniques

Keywords

  • Cervical ripening
  • Exposure to oestrogens
  • Glycosaminoglycan turnover
  • Lysosomes
  • Uterine cervix

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Medicine(all)

Cite this

Increased lysosomal fragility in the human uterine cervix following estrogen therapy. / Herczeg, J.; Borsodi, A.

In: Archives of Gynecology, Vol. 236, No. 3, 04.1985, p. 131-133.

Research output: Contribution to journalArticle

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