Increased levels of anti-heat-shock protein 60 (anti-Hsp60) indicate endothelial dysfunction, atherosclerosis and cardiovascular diseases in patients with mixed connective tissue disease

E. Bodolay, Z. Prohászka, G. Paragh, I. Csípő, G. Nagy, Renata Laczik, Nora Demeter, Eva Zöld, Britt Nakken, G. Szegedi, Peter Szodoray

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Abstract

Heat-shock protein 60 (Hsp60) has been shown to provoke inflammation, and anti-Hsp60 may facilitate the development of atherosclerosis. In this study, we have investigated 30 patients with mixed connective tissue disease (MCTD) and assessed anti-Hsp60 and their relationship to cardiovascular diseases (CVD). Out of 30 patients with MCTD, 15 had CVDs. Anti-Hsp60 antibody was determined by enzyme-linked immunosorbent assay. Since endothelial dysfunction and accelerated atherosclerosis are characteristic to MCTD, a wide array of MCTD-, endothelial dysfunction- and CVD-associated parameters was investigated: serum lipid levels, paraoxonase activity (PON1), rich nuclear ribonucleoprotein U1 (anti-U1RNP), anti-endothelial cell antibodies, anti-cardiolipin and anti-β2-glycoprotein I antibody isotypes (anti-CL and anti-β2GPI), endothelin-1 (ET-1) levels, also intima–media thickness (IMT), a quantitative indicator of atherosclerosis. In MCTD, anti-Hsp60 antibody levels were significantly higher than in healthy individuals (p 

Original languageEnglish
Pages (from-to)50-59
Number of pages10
JournalImmunologic Research
Volume60
Issue number1
DOIs
Publication statusPublished - 2014

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Mixed Connective Tissue Disease
Chaperonin 60
Atherosclerosis
Cardiovascular Diseases
Aryldialkylphosphatase
Cardiolipins
Ribonucleoproteins
Antibodies
Endothelin-1
Anti-Idiotypic Antibodies
Glycoproteins
Enzyme-Linked Immunosorbent Assay
Inflammation
Lipids
Serum

Keywords

  • Anti-Hsp60 antibody
  • Atherosclerosis
  • Cardiovascular disease
  • Dyslipidemia
  • Endothelial dysfunction
  • Mixed connective tissue disease

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Cite this

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abstract = "Heat-shock protein 60 (Hsp60) has been shown to provoke inflammation, and anti-Hsp60 may facilitate the development of atherosclerosis. In this study, we have investigated 30 patients with mixed connective tissue disease (MCTD) and assessed anti-Hsp60 and their relationship to cardiovascular diseases (CVD). Out of 30 patients with MCTD, 15 had CVDs. Anti-Hsp60 antibody was determined by enzyme-linked immunosorbent assay. Since endothelial dysfunction and accelerated atherosclerosis are characteristic to MCTD, a wide array of MCTD-, endothelial dysfunction- and CVD-associated parameters was investigated: serum lipid levels, paraoxonase activity (PON1), rich nuclear ribonucleoprotein U1 (anti-U1RNP), anti-endothelial cell antibodies, anti-cardiolipin and anti-β2-glycoprotein I antibody isotypes (anti-CL and anti-β2GPI), endothelin-1 (ET-1) levels, also intima–media thickness (IMT), a quantitative indicator of atherosclerosis. In MCTD, anti-Hsp60 antibody levels were significantly higher than in healthy individuals (p ",
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AU - Bodolay, E.

AU - Prohászka, Z.

AU - Paragh, G.

AU - Csípő, I.

AU - Nagy, G.

AU - Laczik, Renata

AU - Demeter, Nora

AU - Zöld, Eva

AU - Nakken, Britt

AU - Szegedi, G.

AU - Szodoray, Peter

PY - 2014

Y1 - 2014

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