Increased interictal spike activity associated with transient slow wave trains during non-rapid eye movement sleep

Péter Przemyslaw Ujma, Péter Simor, Raffaele Ferri, Dániel Fabó, Anna Kelemen, Loránd Eross, Róbert Bódizs, Péter Halász

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Non-rapid eye movement (NREM) sleep is characterized by recurring transient events (Cyclic Alternating Patterns, CAP), some of which consist of increased slow wave activity (A1 subtype). Such transient slow-wave events may play an important role in NREM sleep regulation and are known to facilitate epileptiform activity. In our study we investigated the relationship between interictal spike activity and Cyclic Alternating Patterns in three epileptic patients, using simultaneous scalp electroencephalogram (EEG) recording and intracranial electrocorticography. A significant increase of interictal activity was found during CAP A1 subtypes. A positive correlation between scalp EEG delta power and spike activity was found only in CAP A1 subtypes, but not during other events. These results show that transient (but not subcontinuous) delta activity has a facilitating effect on epileptoform activity, also suggesting a functional dissociation between morphologically similar delta activities.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalSleep and Biological Rhythms
Volume13
Issue number2
DOIs
Publication statusPublished - Apr 1 2015

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Keywords

  • Cyclic Alternating Pattern
  • Electroencephalogram power analysis
  • Epilepsy
  • Interictal spikes
  • Intracranial corticography
  • Non-rapid eye movement sleep

ASJC Scopus subject areas

  • Physiology
  • Neuropsychology and Physiological Psychology
  • Neurology
  • Physiology (medical)

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