Increased heme oxygenase-1 expression in premature infants with respiratory distress syndrome

Ildikó Farkas, Zoltán Maróti, M. Katona, E. Endreffy, Péter Monostori, Krisztina Máder, S. Túri

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Oxidative stress is known to play an important role in the pathogenesis of certain severe illnesses in preterm infants. The enzyme heme oxygenase-1 (HO-1) participates in cytoprotection against oxygen radical injury. We have previously described the role of HO-1 in physiologic adaptation by demonstrating the induction of HO-1 in healthy mature neonates and asymptomatic preterm infants. Our current aim was to investigate the HO-1 expression in preterm infants with respiratory distress syndrome (RDS). We collected venous blood samples from 28 preterm infants with RDS on the 1st, 3rd and 5th days after birth. The HO-1 mRNA expression was determined by means of a competitive reverse transcriptase PCR technique, and a quantitative blood count was performed on the residual blood sample. A significant increase in HO-1 expression was found in the preterm infants with RDS as compared with both the healthy mature and the asymptomatic premature groups. The elevation was approximately eight-fold. The platelet count displayed a significant negative association with the HO-1 expression, and in the RDS prematures with thrombocytopenia the HO-1 induction was significantly greater than in those with a normal platelet count. In conclusion, the RDS of prematures is accompanied by an elevated HO-1 expression during the first 5 days of life, consistent with the inflammatory and oxidative characteristics of the disease.

Original languageEnglish
Pages (from-to)1379-1383
Number of pages5
JournalEuropean Journal of Pediatrics
Volume167
Issue number12
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Heme Oxygenase-1
Premature Infants
Newborn Respiratory Distress Syndrome
Platelet Count
Physiological Adaptation
Respiratory Distress Syndrome In Premature Infants
Cytoprotection
Reverse Transcriptase Polymerase Chain Reaction
Thrombocytopenia
Reactive Oxygen Species
Oxidative Stress
Parturition
Newborn Infant
Messenger RNA
Wounds and Injuries

Keywords

  • Gene expression
  • Heme oxygenase-1
  • Respiratory distress syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Increased heme oxygenase-1 expression in premature infants with respiratory distress syndrome. / Farkas, Ildikó; Maróti, Zoltán; Katona, M.; Endreffy, E.; Monostori, Péter; Máder, Krisztina; Túri, S.

In: European Journal of Pediatrics, Vol. 167, No. 12, 12.2008, p. 1379-1383.

Research output: Contribution to journalArticle

Farkas, Ildikó ; Maróti, Zoltán ; Katona, M. ; Endreffy, E. ; Monostori, Péter ; Máder, Krisztina ; Túri, S. / Increased heme oxygenase-1 expression in premature infants with respiratory distress syndrome. In: European Journal of Pediatrics. 2008 ; Vol. 167, No. 12. pp. 1379-1383.
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