Increased FADS2-derived n-6 PUFAs and reduced n-3 PUFAs in plasma of atopic dermatitis patients

Johanna Mihály, Tamás Marosvölgyi, Andrea Szegedi, Krisztina Köröskényi, Renata Lucas, Dániel Törcsik, Ada L. Garcia, Tamás Decsi, Ralph Rühl

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Fatty acid concentrations, in particular n-3 and n-6 polyunsaturated fatty acids (PUFAs), have been described to be dysregulated in atopic dermatitis (AD) patients. The role of genetic polymorphisms of fatty acid enzymes in AD is controversial. We determined in a Hungarian cohort of healthy volunteers (n = 20) and AD patients (n = 20) triglyceride-, sterol- and phospholipid-bound fatty acids in the plasma, mRNA expression of fatty acid desaturase 2 (FADS2) and stearoyl-coenzyme A desaturase 1 in peripheral blood mononuclear cells (PBMCs) and FADS2 concentrations in plasma. We observed higher levels of monounsaturated fatty acids, 16:1 versus 16:0 ratios in phospholipids, triglycerides and sterol esters in patients compared to healthy subjects. In addition higher levels of the FADS2-derived n-6 PUFAs γ-linolenic acid and dihomo-γ-linolenic acid were observed in PBMCs of patients as well as lower levels of n-3 PUFAs. We conclude that the increased expression of FADS2 in PBMCs, as a representative tissue accessible from human blood of AD patients, might be responsible for higher levels of FADS2-derived n-6 PUFAs and lower n-3 PUFA levels in patients.

Original languageEnglish
Pages (from-to)242-248
Number of pages7
JournalSkin Pharmacology and Physiology
Volume27
Issue number5
DOIs
Publication statusPublished - Jul 2014

Keywords

  • Atopic dermatitis
  • Fatty acid desaturase 2
  • Lipid enzymes
  • n-3 polyunsaturated fatty acids
  • n-6 polyunsaturated fatty acids

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Dermatology

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