Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma

Gabriella Czifra, Attila Varga, Katalin Nyeste, Rita Marincsák, Balázs I. Tóth, Ilona Kovács, László Kovács, Tamás Bíró

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69 Citations (Scopus)

Abstract

Purpose: Recently, functional cannabinoid receptor-1 (CB1) and vanilloid receptor-1 (TRPV1) have been described in human prostate and prostate cancer-derived cell lines where the activation of the receptors resulted in inhibition of cellular growth. We, however, lack the description of the expression of these molecules in human prostate cancer (PCC) and in benign prostate hyperplasia (BPH). Methods: Therefore, immunohistochemistry, Western blotting, and quantitative "real-time Q-PCR were performed to define the expressions of CB1 and TRPV1 in healthy and diseased prostate tissues. Results: CB1 was identified in epithelial and smooth muscle cells types of the human prostate, whereas TRPV1 was exclusively localized to the mucosal cells. We also found that the expression of CB1 and TRPV1 (both at the protein and mRNA levels) were significantly up-regulated in PCC. However, while the increased expression of TRPV1 showed a proper correlation with increasing PCC tumor grades, such phenomenon was not observed with CB1. In addition, we also measured markedly elevated CB1 levels in BPH tissues whilst the expression of TRPV1 was not altered when compared to healthy control prostate. Conclusions: Our findings strongly argue for that (1) the CB1 and TRPV1 molecules as well as their ligands may indeed possess a promising future role in the treatment of PCC; (2) TRPV1 may also serve as a prognostic factor in PCC; and (3) CB1 may act as a potential target molecule in the therapeutic management of BPH.

Original languageEnglish
Pages (from-to)507-514
Number of pages8
JournalJournal of cancer research and clinical oncology
Volume135
Issue number4
DOIs
Publication statusPublished - Apr 1 2009

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Keywords

  • Benign prostate hyperplasia
  • Cannabinoid receptor-1 (CB1)
  • Human prostate carcinoma
  • Transient receptor potential vanilloid-1 (TRPV1)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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