Increased D-glucaric acid excretion in children with renal disease

I. Németh, T. Szeleczki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In 85 infants and children, non-specific microsomal enzyme activity was assessed by measuring the urinary D-glucaric acid excretion. In patients with renal disease of various etiology, a highly significant increase in the D-glucaric acid excretion was observed at an early stage of the illness. This change was most marked in patients suffering from tubulopathy and pyelonephritis. Excretion of D-glucaric acid was significantly more pronounced in patients with renal disease than in controls, even in those groups of infants and children who were given enzyme-inducing drugs. As an explanation for the elevation of urinary D-glucaric acid levels in patients with mild renal disease, the possibility and biochemical mechanism of an induction of drug metabolizing enzymes are discussed and some therapeutic conclusions are drawn.

Original languageEnglish
Pages (from-to)357-360
Number of pages4
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Volume18
Issue number8
Publication statusPublished - 1980

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Glucaric Acid
Kidney
Enzymes
Pyelonephritis
Enzyme activity
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Toxicology

Cite this

Increased D-glucaric acid excretion in children with renal disease. / Németh, I.; Szeleczki, T.

In: International Journal of Clinical Pharmacology Therapy and Toxicology, Vol. 18, No. 8, 1980, p. 357-360.

Research output: Contribution to journalArticle

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