Increased circulating heat shock protein 70 levels in pregnant asthmatics

L. Tamási, Anikó Bohács, V. Tamási, Balázs Stenczer, Z. Prohászka, J. Rigó, G. Losonczy, A. Molvarec

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Asthma is one of the most common diseases complicating pregnancy and represents a risk factor for several maternal and perinatal complications. The natural history of asthma is known to change in pregnancy, but very few data are available in the terms of pathomechanism of this change during gestation. Circulating heat shock protein 70 (Hsp70) levels are decreased in healthy pregnancy, which might reflect physiological immunotolerance. The aim of our study was to determine the serum levels of Hsp70 in asthmatic women during gestation. Forty pregnant women with bronchial asthma and 40 healthy pregnant women matched for maternal and gestational age were involved in this case-control study. Serum Hsp70 levels were measured using the ELISA Kit of R&D Systems. Spirometry and oxygen saturation measurements were performed in asthmatic patients. In asthmatic pregnant women, an increase of serum Hsp70 levels was observed compared to healthy pregnant women (median (25-75 percentile): 0.44 ng/ml (0.36-0.53) versus 0.21 ng/ml (0-0.27), p

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalCell Stress and Chaperones
Volume15
Issue number3
DOIs
Publication statusPublished - May 2010

Fingerprint

HSP70 Heat-Shock Proteins
Pregnant Women
Pregnancy
Asthma
Blood Proteins
Spirometry
Maternal Age
Gestational Age
Case-Control Studies
Oxygen
Enzyme-Linked Immunosorbent Assay
Mothers
Serum

Keywords

  • Asthma
  • Heat shock protein
  • Immunological tolerance
  • Pregnancy

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Increased circulating heat shock protein 70 levels in pregnant asthmatics. / Tamási, L.; Bohács, Anikó; Tamási, V.; Stenczer, Balázs; Prohászka, Z.; Rigó, J.; Losonczy, G.; Molvarec, A.

In: Cell Stress and Chaperones, Vol. 15, No. 3, 05.2010, p. 295-300.

Research output: Contribution to journalArticle

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