Increased circulating anti-α6-integrin autoantibodies in psoriasis and psoriatic arthritis but not in rheumatoid arthritis

Brigitta Gál, Sonja Dulic, Mária Kiss, Gergely Groma, László Kovács, Lajos Kemény, Zsuzsanna Bata-Csörgő

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In psoriatic skin, laminin integrity is altered, which could lead to insufficient laminin integrin interactions, leaving the α6-integrin exposed and possibly accessible for autoantibody production. Therefore we investigated the presence of anti-α6-integrin autoantibodies in the serum of patients with psoriasis vulgaris (Ps), psoriatic arthritis (PsA) and rheumatoid arthritis (RA) in comparison with healthy donors. The level of circulating anti-α6-integrin antibodies was determined by enzyme-linked immunoassay using α6-integrin fragments. Antibodies against at least one recombinant fragment were found in approximately 30% of Ps and PsA patients. In contrast, in RA patients, the frequency of antibodies was similar to healthy controls. Our study shows the presence of anti-α6-integrin antibodies in Ps and PsA but not in RA, which could indicate ongoing abnormal processes in the skin. Anti-α6-integrin autoantibodies may contribute to the formation of micro-wounds in the skin and to the characteristic wound-healing phenotype in psoriasis.

Original languageEnglish
Pages (from-to)370-374
Number of pages5
JournalJournal of Dermatology
Volume44
Issue number4
DOIs
Publication statusPublished - Apr 1 2017

Keywords

  • alpha-6-integrin
  • antibodies
  • psoriasis
  • psoriatic arthritis
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Dermatology

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