Increased c-Jun expression in neurons affected by lysolecithin-induced demyelination in rats

Gábor Lovas, M. Palkóvits, S. Komoly

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The objective of this study was to investigate whether the expression of c-Jun is involved in the neuronal response to experimental demyelination. Lysolecithin-induced demyelination was generated in two distinct neural systems in rats: in the pontocerebellar and the septohippocampal pathways. Six days after the stereotaxic injections of lysolecithin, expression of the immediate early gene c-Jun was visualized by immunohistochemistry. Lesion-specific expression of the Jun protein was observed in neurons whose axons transverse the demyelinated area. Unlike the neural response to axotomy, lysolecithin treatment did not alter the expression of the neuropeptide galanin in the septohippocampal pathway. These results suggest that c-Jun protein expression might represent one step in the neuronal response to demyelination and that this response might be distinct in its downstream events from axotomy. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalNeuroscience Letters
Volume292
Issue number2
DOIs
Publication statusPublished - Oct 6 2000

Fingerprint

Lysophosphatidylcholines
Demyelinating Diseases
Axotomy
Neurons
Proto-Oncogene Proteins c-jun
Galanin
Immediate-Early Genes
Neuropeptides
Axons
Immunohistochemistry
Injections
Proteins
Therapeutics

Keywords

  • c-Jun
  • Galanin
  • Lysolecithin-induced demyelination

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Increased c-Jun expression in neurons affected by lysolecithin-induced demyelination in rats. / Lovas, Gábor; Palkóvits, M.; Komoly, S.

In: Neuroscience Letters, Vol. 292, No. 2, 06.10.2000, p. 71-74.

Research output: Contribution to journalArticle

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