Increased binding of calcium in the hippocampal slice during long-term potentiation

U. Kuhnt, A. Mihály, F. Joó

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Long-term potentiation (LTP) of CA1 pyramidal neurons was induced by tetanic stimulation in the stratum radiatum of hippocampal slices from guinea pigs. Unstimulated and stimulated slices were treated using a histochemical procedure enabling the electron microscopic (EM) visualization of Ca binding sites. Electron-dense, Ca-containing deposits were found in low numbers in unstimulated slices on pre- and postsynaptic sites. In the stratum radiatum of tetanized slices the overall number of deposits as well as the number of deposits in dendrites was clearly increased. The results support the hypothesis that Ca-dependent postsynaptic mechanisms are important for the generation of LTP.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalNeuroscience Letters
Volume53
Issue number2
DOIs
Publication statusPublished - Jan 21 1985

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Long-Term Potentiation
Electrons
Calcium
Pyramidal Cells
Dendrites
Guinea Pigs
Binding Sites

Keywords

  • calcium
  • guinea pig
  • hippocampus
  • histochemistry
  • in vitro
  • long-term potentiation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Increased binding of calcium in the hippocampal slice during long-term potentiation. / Kuhnt, U.; Mihály, A.; Joó, F.

In: Neuroscience Letters, Vol. 53, No. 2, 21.01.1985, p. 149-154.

Research output: Contribution to journalArticle

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