Increased B-type natriuretic peptide levels in early-onset versus late-onset preeclampsia

Gábor Szabó, A. Molvarec, B. Nagy, J. Rigó

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: We compared B-type natriuretic peptide (BNP) levels, clinical and laboratory findings in earlyonset preeclampsia (EOP), late-onset preeclampsia (LOP)and healthy pregnant groups.Methods: We studied 40 healthy pregnant and 40 preeclamptic patients. Preeclamptics were divided in two groups, the EOP group (n = 20) and LOP group (n = 20),according to gestational age at the onset of disease. The distinction criterion for early- vs. late-onset was set as week 34 of gestation. The concentration of the BNP levels was measured by a sandwich fluorescence immunoassay. For statistical analysis of the clinical and laboratory findings non-parametric methods were applied. Results: BNP levels were higher in EOP [61.35 (36.95-93.25)pg/mL] and LOP patients [32.4 (19.15-39.2) pg/mL] than in healthy pregnant women [10.05 (6.08-16.03) pg/mL](both p <0.001). Furthermore, EOPs had significantly higher BNP levels as compared to LOP patients (p <0.001). A BNP cut-off <24.5 pg/mL had a negative-predictive value of 85.1% excluding preeclampsia. There was a significantinverse correlation between plasma BNP levels of EOP patients and sodium (p <0.05) and total protein concentrations (p <0.05). In the EOP group, a significant positive correlation was observed between plasma levels of BNP and hematocrit (p <0.05), serum potassium (p <0.05), urea (p <0.05) and 24-h proteinuria (p <0.05). Conclusions: BNP levels were significantly higher in EOP than in LOP patients. The cut-off value <24.5 pg/mL seems to be a powerful discriminative indicator excluding preeclampsia. The amount of proteinuria and total protein levels correlate with the elevation of the BNP levels. In EOP the extent of proteinuria is higher than in the LOP.

Original languageEnglish
Pages (from-to)281-288
Number of pages8
JournalClinical Chemistry and Laboratory Medicine
Volume52
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Brain Natriuretic Peptide
Pre-Eclampsia
Proteinuria
Plasmas
Urea
Statistical methods
Potassium
Proteins
Sodium
Fluorescence
Hematocrit
Age of Onset
Immunoassay
Gestational Age
Pregnant Women

Keywords

  • B-type natriuretic peptide
  • Early-onset
  • Lateonset
  • Preeclampsia
  • Proteinuria

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

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title = "Increased B-type natriuretic peptide levels in early-onset versus late-onset preeclampsia",
abstract = "Background: We compared B-type natriuretic peptide (BNP) levels, clinical and laboratory findings in earlyonset preeclampsia (EOP), late-onset preeclampsia (LOP)and healthy pregnant groups.Methods: We studied 40 healthy pregnant and 40 preeclamptic patients. Preeclamptics were divided in two groups, the EOP group (n = 20) and LOP group (n = 20),according to gestational age at the onset of disease. The distinction criterion for early- vs. late-onset was set as week 34 of gestation. The concentration of the BNP levels was measured by a sandwich fluorescence immunoassay. For statistical analysis of the clinical and laboratory findings non-parametric methods were applied. Results: BNP levels were higher in EOP [61.35 (36.95-93.25)pg/mL] and LOP patients [32.4 (19.15-39.2) pg/mL] than in healthy pregnant women [10.05 (6.08-16.03) pg/mL](both p <0.001). Furthermore, EOPs had significantly higher BNP levels as compared to LOP patients (p <0.001). A BNP cut-off <24.5 pg/mL had a negative-predictive value of 85.1{\%} excluding preeclampsia. There was a significantinverse correlation between plasma BNP levels of EOP patients and sodium (p <0.05) and total protein concentrations (p <0.05). In the EOP group, a significant positive correlation was observed between plasma levels of BNP and hematocrit (p <0.05), serum potassium (p <0.05), urea (p <0.05) and 24-h proteinuria (p <0.05). Conclusions: BNP levels were significantly higher in EOP than in LOP patients. The cut-off value <24.5 pg/mL seems to be a powerful discriminative indicator excluding preeclampsia. The amount of proteinuria and total protein levels correlate with the elevation of the BNP levels. In EOP the extent of proteinuria is higher than in the LOP.",
keywords = "B-type natriuretic peptide, Early-onset, Lateonset, Preeclampsia, Proteinuria",
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TY - JOUR

T1 - Increased B-type natriuretic peptide levels in early-onset versus late-onset preeclampsia

AU - Szabó, Gábor

AU - Molvarec, A.

AU - Nagy, B.

AU - Rigó, J.

PY - 2014

Y1 - 2014

N2 - Background: We compared B-type natriuretic peptide (BNP) levels, clinical and laboratory findings in earlyonset preeclampsia (EOP), late-onset preeclampsia (LOP)and healthy pregnant groups.Methods: We studied 40 healthy pregnant and 40 preeclamptic patients. Preeclamptics were divided in two groups, the EOP group (n = 20) and LOP group (n = 20),according to gestational age at the onset of disease. The distinction criterion for early- vs. late-onset was set as week 34 of gestation. The concentration of the BNP levels was measured by a sandwich fluorescence immunoassay. For statistical analysis of the clinical and laboratory findings non-parametric methods were applied. Results: BNP levels were higher in EOP [61.35 (36.95-93.25)pg/mL] and LOP patients [32.4 (19.15-39.2) pg/mL] than in healthy pregnant women [10.05 (6.08-16.03) pg/mL](both p <0.001). Furthermore, EOPs had significantly higher BNP levels as compared to LOP patients (p <0.001). A BNP cut-off <24.5 pg/mL had a negative-predictive value of 85.1% excluding preeclampsia. There was a significantinverse correlation between plasma BNP levels of EOP patients and sodium (p <0.05) and total protein concentrations (p <0.05). In the EOP group, a significant positive correlation was observed between plasma levels of BNP and hematocrit (p <0.05), serum potassium (p <0.05), urea (p <0.05) and 24-h proteinuria (p <0.05). Conclusions: BNP levels were significantly higher in EOP than in LOP patients. The cut-off value <24.5 pg/mL seems to be a powerful discriminative indicator excluding preeclampsia. The amount of proteinuria and total protein levels correlate with the elevation of the BNP levels. In EOP the extent of proteinuria is higher than in the LOP.

AB - Background: We compared B-type natriuretic peptide (BNP) levels, clinical and laboratory findings in earlyonset preeclampsia (EOP), late-onset preeclampsia (LOP)and healthy pregnant groups.Methods: We studied 40 healthy pregnant and 40 preeclamptic patients. Preeclamptics were divided in two groups, the EOP group (n = 20) and LOP group (n = 20),according to gestational age at the onset of disease. The distinction criterion for early- vs. late-onset was set as week 34 of gestation. The concentration of the BNP levels was measured by a sandwich fluorescence immunoassay. For statistical analysis of the clinical and laboratory findings non-parametric methods were applied. Results: BNP levels were higher in EOP [61.35 (36.95-93.25)pg/mL] and LOP patients [32.4 (19.15-39.2) pg/mL] than in healthy pregnant women [10.05 (6.08-16.03) pg/mL](both p <0.001). Furthermore, EOPs had significantly higher BNP levels as compared to LOP patients (p <0.001). A BNP cut-off <24.5 pg/mL had a negative-predictive value of 85.1% excluding preeclampsia. There was a significantinverse correlation between plasma BNP levels of EOP patients and sodium (p <0.05) and total protein concentrations (p <0.05). In the EOP group, a significant positive correlation was observed between plasma levels of BNP and hematocrit (p <0.05), serum potassium (p <0.05), urea (p <0.05) and 24-h proteinuria (p <0.05). Conclusions: BNP levels were significantly higher in EOP than in LOP patients. The cut-off value <24.5 pg/mL seems to be a powerful discriminative indicator excluding preeclampsia. The amount of proteinuria and total protein levels correlate with the elevation of the BNP levels. In EOP the extent of proteinuria is higher than in the LOP.

KW - B-type natriuretic peptide

KW - Early-onset

KW - Lateonset

KW - Preeclampsia

KW - Proteinuria

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