Abstract
Newborn rats were treated with a single dose of vitamin A (retinol) and apoptosis of peripheral lymphocytes was studied by flow cytometry in adult age. Vitamin A treatment (hormonal imprinting) caused a moderate, however significant elevation in the number of apoptotic lymphocytes after three months. Dexamethasone or Concanavalin-A alone did not influence apoptosis significantly. However, in the neonatally retinol treated rats dexamathasone significantly elevated the quantity of apoptotic lymphocytes related to the control or Concanavalin-A treated control cells. The results call attention to the prolonged effect of hormonal imprinting in a new index and to the possible dangerous effects in human, neonatally treated with vitamin A.
| Original language | English |
|---|---|
| Journal | Life Sciences |
| Volume | 61 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - Oct 31 1997 |
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Keywords
- Apoptosis
- Hormonal imprinting
- Programmed cell death
- Retinoids
- Vitamin A
ASJC Scopus subject areas
- Pharmacology
Cite this
Increased apoptosis of adult rat lymphocytes after single neonatal vitamin A treatment (hormonal imprinting). A follow cytometric analysis. / Gaál, Annamária; Bocsi, J.; Falus, A.; Szende, B.; Csaba, G.
In: Life Sciences, Vol. 61, No. 23, 31.10.1997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased apoptosis of adult rat lymphocytes after single neonatal vitamin A treatment (hormonal imprinting). A follow cytometric analysis
AU - Gaál, Annamária
AU - Bocsi, J.
AU - Falus, A.
AU - Szende, B.
AU - Csaba, G.
PY - 1997/10/31
Y1 - 1997/10/31
N2 - Newborn rats were treated with a single dose of vitamin A (retinol) and apoptosis of peripheral lymphocytes was studied by flow cytometry in adult age. Vitamin A treatment (hormonal imprinting) caused a moderate, however significant elevation in the number of apoptotic lymphocytes after three months. Dexamethasone or Concanavalin-A alone did not influence apoptosis significantly. However, in the neonatally retinol treated rats dexamathasone significantly elevated the quantity of apoptotic lymphocytes related to the control or Concanavalin-A treated control cells. The results call attention to the prolonged effect of hormonal imprinting in a new index and to the possible dangerous effects in human, neonatally treated with vitamin A.
AB - Newborn rats were treated with a single dose of vitamin A (retinol) and apoptosis of peripheral lymphocytes was studied by flow cytometry in adult age. Vitamin A treatment (hormonal imprinting) caused a moderate, however significant elevation in the number of apoptotic lymphocytes after three months. Dexamethasone or Concanavalin-A alone did not influence apoptosis significantly. However, in the neonatally retinol treated rats dexamathasone significantly elevated the quantity of apoptotic lymphocytes related to the control or Concanavalin-A treated control cells. The results call attention to the prolonged effect of hormonal imprinting in a new index and to the possible dangerous effects in human, neonatally treated with vitamin A.
KW - Apoptosis
KW - Hormonal imprinting
KW - Programmed cell death
KW - Retinoids
KW - Vitamin A
UR - http://www.scopus.com/inward/record.url?scp=0343488373&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0343488373&partnerID=8YFLogxK
U2 - 10.1016/S0024-3205(97)00940-5
DO - 10.1016/S0024-3205(97)00940-5
M3 - Article
VL - 61
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 23
ER -