Increased apoptosis of adult rat lymphocytes after single neonatal vitamin A treatment (hormonal imprinting). A follow cytometric analysis

Annamária Gaál, J. Bocsi, A. Falus, B. Szende, G. Csaba

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4 Citations (Scopus)

Abstract

Newborn rats were treated with a single dose of vitamin A (retinol) and apoptosis of peripheral lymphocytes was studied by flow cytometry in adult age. Vitamin A treatment (hormonal imprinting) caused a moderate, however significant elevation in the number of apoptotic lymphocytes after three months. Dexamethasone or Concanavalin-A alone did not influence apoptosis significantly. However, in the neonatally retinol treated rats dexamathasone significantly elevated the quantity of apoptotic lymphocytes related to the control or Concanavalin-A treated control cells. The results call attention to the prolonged effect of hormonal imprinting in a new index and to the possible dangerous effects in human, neonatally treated with vitamin A.

Original languageEnglish
JournalLife Sciences
Volume61
Issue number23
DOIs
Publication statusPublished - Oct 31 1997

Fingerprint

Lymphocytes
Vitamin A
Rats
Apoptosis
Concanavalin A
Flow cytometry
Lymphocyte Count
Dexamethasone
Flow Cytometry

Keywords

  • Apoptosis
  • Hormonal imprinting
  • Programmed cell death
  • Retinoids
  • Vitamin A

ASJC Scopus subject areas

  • Pharmacology

Cite this

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abstract = "Newborn rats were treated with a single dose of vitamin A (retinol) and apoptosis of peripheral lymphocytes was studied by flow cytometry in adult age. Vitamin A treatment (hormonal imprinting) caused a moderate, however significant elevation in the number of apoptotic lymphocytes after three months. Dexamethasone or Concanavalin-A alone did not influence apoptosis significantly. However, in the neonatally retinol treated rats dexamathasone significantly elevated the quantity of apoptotic lymphocytes related to the control or Concanavalin-A treated control cells. The results call attention to the prolonged effect of hormonal imprinting in a new index and to the possible dangerous effects in human, neonatally treated with vitamin A.",
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T1 - Increased apoptosis of adult rat lymphocytes after single neonatal vitamin A treatment (hormonal imprinting). A follow cytometric analysis

AU - Gaál, Annamária

AU - Bocsi, J.

AU - Falus, A.

AU - Szende, B.

AU - Csaba, G.

PY - 1997/10/31

Y1 - 1997/10/31

N2 - Newborn rats were treated with a single dose of vitamin A (retinol) and apoptosis of peripheral lymphocytes was studied by flow cytometry in adult age. Vitamin A treatment (hormonal imprinting) caused a moderate, however significant elevation in the number of apoptotic lymphocytes after three months. Dexamethasone or Concanavalin-A alone did not influence apoptosis significantly. However, in the neonatally retinol treated rats dexamathasone significantly elevated the quantity of apoptotic lymphocytes related to the control or Concanavalin-A treated control cells. The results call attention to the prolonged effect of hormonal imprinting in a new index and to the possible dangerous effects in human, neonatally treated with vitamin A.

AB - Newborn rats were treated with a single dose of vitamin A (retinol) and apoptosis of peripheral lymphocytes was studied by flow cytometry in adult age. Vitamin A treatment (hormonal imprinting) caused a moderate, however significant elevation in the number of apoptotic lymphocytes after three months. Dexamethasone or Concanavalin-A alone did not influence apoptosis significantly. However, in the neonatally retinol treated rats dexamathasone significantly elevated the quantity of apoptotic lymphocytes related to the control or Concanavalin-A treated control cells. The results call attention to the prolonged effect of hormonal imprinting in a new index and to the possible dangerous effects in human, neonatally treated with vitamin A.

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KW - Programmed cell death

KW - Retinoids

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