Increased apolipoprotein E4 allele frequency is associated with vascular dementia in the Hungarian population

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29 Citations (Scopus)

Abstract

Introduction - The regulatory role of apolipoprotein E in lipid transport and metabolism was utilized to investigate the allelic association between the apolipoprotein E4 (apoE4) allele and vascular dementia (VD) in a selected sample of Hungarian patients with multiple deep subcortical infarcts and leukoaraiosis. Material and methods - Thirty-four Caucasian VD cases and 79 healthy control probands were involved in this study according to the criteria of ICD-10 and NINDS-AIREN International Workshop Diagnostic Criteria. The genomic DNA was isolated from whole blood and the apoE alleles were determined by polymerase chain reaction. Results - The E2, E3 and E4 allele frequencies in the VD group were 5%, 76%, and 19%, respectively; and significant (P

Original languageEnglish
Pages (from-to)166-168
Number of pages3
JournalActa Neurologica Scandinavica
Volume98
Issue number3
Publication statusPublished - 1998

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Apolipoprotein E4
Vascular Dementia
Gene Frequency
Apolipoproteins E
Leukoaraiosis
Alleles
National Institute of Neurological Disorders and Stroke
Population
International Classification of Diseases
Lipid Metabolism
Education
Polymerase Chain Reaction
DNA

Keywords

  • Allele polymorphism
  • Apolipoprotein E4
  • Hungarian population
  • Vascular dementia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

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title = "Increased apolipoprotein E4 allele frequency is associated with vascular dementia in the Hungarian population",
abstract = "Introduction - The regulatory role of apolipoprotein E in lipid transport and metabolism was utilized to investigate the allelic association between the apolipoprotein E4 (apoE4) allele and vascular dementia (VD) in a selected sample of Hungarian patients with multiple deep subcortical infarcts and leukoaraiosis. Material and methods - Thirty-four Caucasian VD cases and 79 healthy control probands were involved in this study according to the criteria of ICD-10 and NINDS-AIREN International Workshop Diagnostic Criteria. The genomic DNA was isolated from whole blood and the apoE alleles were determined by polymerase chain reaction. Results - The E2, E3 and E4 allele frequencies in the VD group were 5{\%}, 76{\%}, and 19{\%}, respectively; and significant (P",
keywords = "Allele polymorphism, Apolipoprotein E4, Hungarian population, Vascular dementia",
author = "J. K{\'a}lm{\'a}n and A. Juh{\'a}sz and A. Cs{\'a}sz{\'a}r and A. Kanka and A. Riman{\'o}czy and Z. Janka and I. Rask{\'o}",
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TY - JOUR

T1 - Increased apolipoprotein E4 allele frequency is associated with vascular dementia in the Hungarian population

AU - Kálmán, J.

AU - Juhász, A.

AU - Császár, A.

AU - Kanka, A.

AU - Rimanóczy, A.

AU - Janka, Z.

AU - Raskó, I.

PY - 1998

Y1 - 1998

N2 - Introduction - The regulatory role of apolipoprotein E in lipid transport and metabolism was utilized to investigate the allelic association between the apolipoprotein E4 (apoE4) allele and vascular dementia (VD) in a selected sample of Hungarian patients with multiple deep subcortical infarcts and leukoaraiosis. Material and methods - Thirty-four Caucasian VD cases and 79 healthy control probands were involved in this study according to the criteria of ICD-10 and NINDS-AIREN International Workshop Diagnostic Criteria. The genomic DNA was isolated from whole blood and the apoE alleles were determined by polymerase chain reaction. Results - The E2, E3 and E4 allele frequencies in the VD group were 5%, 76%, and 19%, respectively; and significant (P

AB - Introduction - The regulatory role of apolipoprotein E in lipid transport and metabolism was utilized to investigate the allelic association between the apolipoprotein E4 (apoE4) allele and vascular dementia (VD) in a selected sample of Hungarian patients with multiple deep subcortical infarcts and leukoaraiosis. Material and methods - Thirty-four Caucasian VD cases and 79 healthy control probands were involved in this study according to the criteria of ICD-10 and NINDS-AIREN International Workshop Diagnostic Criteria. The genomic DNA was isolated from whole blood and the apoE alleles were determined by polymerase chain reaction. Results - The E2, E3 and E4 allele frequencies in the VD group were 5%, 76%, and 19%, respectively; and significant (P

KW - Allele polymorphism

KW - Apolipoprotein E4

KW - Hungarian population

KW - Vascular dementia

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M3 - Article

VL - 98

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