Increased activation of the pregenual anterior cingulate cortex to citalopram challenge in migraine: An fMRI study

Andrea Edit Edes, Shane McKie, Edina Szabo, Gyongyi Kokonyei, Dorottya Pap, Terezia Zsombok, Mate Magyar, Eva Csepany, Gabor Hullam, Adam Gyorgy Szabo, Lajos Rudolf Kozak, Gyorgy Bagdy, Gabriella Juhasz

Research output: Contribution to journalArticle

Abstract

Background: The anterior cingulate cortex (ACC) is a key structure of the pain processing network. Several structural and functional alterations of this brain area have been found in migraine. In addition, altered serotonergic neurotransmission has been repeatedly implicated in the pathophysiology of migraine, although the exact mechanism is not known. Thus, our aim was to investigate the relationship between acute increase of brain serotonin (5-HT) level and the activation changes of the ACC using pharmacological challenge MRI (phMRI) in migraine patients and healthy controls. Methods: Twenty-seven pain-free healthy controls and six migraine without aura patients participated in the study. All participant attended to two phMRI sessions during which intravenous citalopram, a selective serotonin reuptake inhibitor (SSRI), or placebo (normal saline) was administered. We used region of interest analysis of ACC to compere the citalopram evoked activation changes of this area between patients and healthy participants. Results: Significant difference in ACC activation was found between control and patient groups in the right pregenual ACC (pgACC) during and after citalopram infusion compared to placebo. The extracted time-series showed that pgACC activation increased in migraine patients compared to controls, especially in the first 8-10 min of citalopram infusion. Conclusions: Our results demonstrate that a small increase in 5-HT levels can lead to increased phMRI signal in the pregenual part of the ACC that is involved in processing emotional aspects of pain. This increased sensitivity of the pgACC to increased 5-HT in migraine may contribute to recurring headache attacks and increased stress-sensitivity in migraine.

Original languageEnglish
Article number237
JournalBMC Neurology
Volume19
Issue number1
DOIs
Publication statusPublished - Oct 15 2019

Keywords

  • Anterior cingulate cortex
  • Citalopram
  • Migraine without aura
  • Pharmacological challenge MRI

ASJC Scopus subject areas

  • Clinical Neurology

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    Edes, A. E., McKie, S., Szabo, E., Kokonyei, G., Pap, D., Zsombok, T., Magyar, M., Csepany, E., Hullam, G., Szabo, A. G., Kozak, L. R., Bagdy, G., & Juhasz, G. (2019). Increased activation of the pregenual anterior cingulate cortex to citalopram challenge in migraine: An fMRI study. BMC Neurology, 19(1), [237]. https://doi.org/10.1186/s12883-019-1478-0