Magasabb homociszteinszint cardiovascularis betegségekben Magyarországon

Translated title of the contribution: Increase of homocysteine in cardiovascular diseases in Hungary

Emília Balogh, István Czuriga, Zsusza Berekczky, Krisztina Boda, Zsolt Koszegi, Csaba Kónya, Albert Császár, László Muszbek, István Édes, Péter Ferdinandy

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Abstract

There are only very few epidemiologiocal data abdut homocysteine levels in patients suffering from cardiovascular (CV) disease in Hungary, however, homocysteine is a newly recognized, independent risk factor of CV diseases. Aim of the study: Therefore, in the present study, data of 1010 East-Hungarian patients with signs of CV disease were analyzed retrospectively for correlation between the level of homocysteine and CV diseases, laboratory parameters, as well as genetic differences. Patients and methods: From the studied patient population a control ("healthy") group has been selected according to the following criteria: lack of previous stroke or stenosis of the carotid arteries or the lower extremities, lack of coronary artery stenosis more than 50%, no previous coronary intervention or an angiography diagnosed progression of the coronary atherosclerosis. Results: The level of homocysteine showed statistically significant negative linear correlation with HDL-cholesterol and the anti-atherogen ApoAI, and showed a positive correlation with CRP and FXIII activities in the entire patient population. When compared to the control group, homocysteine level was significantly higher in patients with previous stroke or acute myocardial infarction, coronary stenosis, progressive coronary disease, physical inactivity, MTHFR gene polymorphism, low folate or vitamin B'12 level in both men and women. In patients with type II diabetes the level of homocysteine was significantly higher only in women. Conclusions: It can be concluded that the level of homocysteine in patients suffering from various CV diseases is high in Hungary. This may have a prognostic value, and shows that reduction of homocysteine level in these patients may be beneficial.

Original languageHungarian
Pages (from-to)1685-1690
Number of pages6
JournalOrvosi hetilap
Volume147
Issue number35
Publication statusPublished - Sep 3 2006

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ASJC Scopus subject areas

  • Medicine(all)

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