Recently we have reported that β-endorphin is able to enhance the ouabain evoked acetylcholine (ACh) release from isolated striatal slices of the rat. In this paper a similar effect was demonstrated for Met5-enkephalin-methylester in a concentration of 10-7-10-5M. D-Ala2-Pro5-enkephalin-amide and D-Met2-Pro5-enkephalin-ethylamide (enzyme resistant peptides) were also capable of increasing transmitter release, while β-Ala2-Met5-enkephalin-methylester, Tyr-β-Ala-Phe-Met-methylester and Tyr-Gly-Gly-Phe-NH-cyclohexyl failed to affect the ouabain induced ACh release. These data indicate the endorphins could take part in the regulation of striatal neurochemical transmission as a transmitter or modulator.
|Number of pages||9|
|Journal||Polish journal of pharmacology and pharmacy|
|Publication status||Published - Dec 1 1978|
ASJC Scopus subject areas
- Pharmaceutical Science