Increase by enkephalin of acetylcholine release from striatal slices of the rat

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Recently we have reported that β-endorphin is able to enhance the ouabain evoked acetylcholine (ACh) release from isolated striatal slices of the rat. In this paper a similar effect was demonstrated for Met5-enkephalin-methylester in a concentration of 10-7-10-5M. D-Ala2-Pro5-enkephalin-amide and D-Met2-Pro5-enkephalin-ethylamide (enzyme resistant peptides) were also capable of increasing transmitter release, while β-Ala2-Met5-enkephalin-methylester, Tyr-β-Ala-Phe-Met-methylester and Tyr-Gly-Gly-Phe-NH-cyclohexyl failed to affect the ouabain induced ACh release. These data indicate the endorphins could take part in the regulation of striatal neurochemical transmission as a transmitter or modulator.

Original languageEnglish
Pages (from-to)387-395
Number of pages9
JournalPolish Journal of Pharmacology and Pharmacy
Volume30
Issue number2-3
Publication statusPublished - 1978

Fingerprint

Corpus Striatum
Enkephalins
Acetylcholine
Endorphins
Ouabain
Methionine Enkephalin
Amides
Peptides
Enzymes

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

@article{a5cbf8fafa904b3daf3960ced626c81c,
title = "Increase by enkephalin of acetylcholine release from striatal slices of the rat",
abstract = "Recently we have reported that β-endorphin is able to enhance the ouabain evoked acetylcholine (ACh) release from isolated striatal slices of the rat. In this paper a similar effect was demonstrated for Met5-enkephalin-methylester in a concentration of 10-7-10-5M. D-Ala2-Pro5-enkephalin-amide and D-Met2-Pro5-enkephalin-ethylamide (enzyme resistant peptides) were also capable of increasing transmitter release, while β-Ala2-Met5-enkephalin-methylester, Tyr-β-Ala-Phe-Met-methylester and Tyr-Gly-Gly-Phe-NH-cyclohexyl failed to affect the ouabain induced ACh release. These data indicate the endorphins could take part in the regulation of striatal neurochemical transmission as a transmitter or modulator.",
author = "L. H{\'a}rsing and E. V{\'i}zi and J. Knoll",
year = "1978",
language = "English",
volume = "30",
pages = "387--395",
journal = "Pharmacological Reports",
issn = "1734-1140",
publisher = "Polish Academy of Sciences Publishing House",
number = "2-3",

}

TY - JOUR

T1 - Increase by enkephalin of acetylcholine release from striatal slices of the rat

AU - Hársing, L.

AU - Vízi, E.

AU - Knoll, J.

PY - 1978

Y1 - 1978

N2 - Recently we have reported that β-endorphin is able to enhance the ouabain evoked acetylcholine (ACh) release from isolated striatal slices of the rat. In this paper a similar effect was demonstrated for Met5-enkephalin-methylester in a concentration of 10-7-10-5M. D-Ala2-Pro5-enkephalin-amide and D-Met2-Pro5-enkephalin-ethylamide (enzyme resistant peptides) were also capable of increasing transmitter release, while β-Ala2-Met5-enkephalin-methylester, Tyr-β-Ala-Phe-Met-methylester and Tyr-Gly-Gly-Phe-NH-cyclohexyl failed to affect the ouabain induced ACh release. These data indicate the endorphins could take part in the regulation of striatal neurochemical transmission as a transmitter or modulator.

AB - Recently we have reported that β-endorphin is able to enhance the ouabain evoked acetylcholine (ACh) release from isolated striatal slices of the rat. In this paper a similar effect was demonstrated for Met5-enkephalin-methylester in a concentration of 10-7-10-5M. D-Ala2-Pro5-enkephalin-amide and D-Met2-Pro5-enkephalin-ethylamide (enzyme resistant peptides) were also capable of increasing transmitter release, while β-Ala2-Met5-enkephalin-methylester, Tyr-β-Ala-Phe-Met-methylester and Tyr-Gly-Gly-Phe-NH-cyclohexyl failed to affect the ouabain induced ACh release. These data indicate the endorphins could take part in the regulation of striatal neurochemical transmission as a transmitter or modulator.

UR - http://www.scopus.com/inward/record.url?scp=0018140322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018140322&partnerID=8YFLogxK

M3 - Article

C2 - 209425

AN - SCOPUS:0018140322

VL - 30

SP - 387

EP - 395

JO - Pharmacological Reports

JF - Pharmacological Reports

SN - 1734-1140

IS - 2-3

ER -