Increase by enkephalin of acetylcholine release from striatal slices of the rat

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Abstract

Recently we have reported that β-endorphin is able to enhance the ouabain evoked acetylcholine (ACh) release from isolated striatal slices of the rat. In this paper a similar effect was demonstrated for Met5-enkephalin-methylester in a concentration of 10-7-10-5M. D-Ala2-Pro5-enkephalin-amide and D-Met2-Pro5-enkephalin-ethylamide (enzyme resistant peptides) were also capable of increasing transmitter release, while β-Ala2-Met5-enkephalin-methylester, Tyr-β-Ala-Phe-Met-methylester and Tyr-Gly-Gly-Phe-NH-cyclohexyl failed to affect the ouabain induced ACh release. These data indicate the endorphins could take part in the regulation of striatal neurochemical transmission as a transmitter or modulator.

Original languageEnglish
Pages (from-to)387-395
Number of pages9
JournalPolish journal of pharmacology and pharmacy
Volume30
Issue number2-3
Publication statusPublished - Dec 1 1978

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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