Incomplete and flow dependent extraction of86Rb in the rat kidney - Errors in local flow estimation

L. Rosivall, A. Hope, G. Clausen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Renal uptake of86Rb, lasting for 30 s after intravenous bolus injection, and uptake of 15 μm radioactive microspheres (Ms) simultaneously injected in the left ventricle were measured in rats. Calculated from renal blood flow (RBF) determined by Ms and86Rb clearance, the renal extraction ratio of86Rb (ERb) was 0.81±0.07 (SD). With increasing RBF, ERb decreased significantly. Total body86Rb extraction ratio nearly equalled ERb as determined 30 s after injection. In another group of rats86Rb was injected into an extracorporal circuit from the carotid artery perfusing the left kidney only. Renal recovery of86Rb averaged 0.76±0.13 15-20s after injection. As in the first group, ERb was inversely related to RBF. At increased RBF, calculated local cortical flow is seriously underestimated unless ERb as well as ERb flow dependency are taken into account. However, the relative local flow rates calculated for cortical zones are not appreciably affected by ERb and its flow dependency.

Original languageEnglish
Pages (from-to)216-218
Number of pages3
JournalPflugers Archiv European Journal of Physiology
Volume390
Issue number3
DOIs
Publication statusPublished - Jun 1981

Fingerprint

Renal Circulation
Rats
Kidney
Microspheres
Blood
Injections
Carotid Arteries
Intravenous Injections
Heart Ventricles
Flow rate
Recovery
Networks (circuits)

Keywords

  • Rb extraction
  • Blood flow distribution
  • Microspheres
  • Renal blood flow

ASJC Scopus subject areas

  • Physiology

Cite this

Incomplete and flow dependent extraction of86Rb in the rat kidney - Errors in local flow estimation. / Rosivall, L.; Hope, A.; Clausen, G.

In: Pflugers Archiv European Journal of Physiology, Vol. 390, No. 3, 06.1981, p. 216-218.

Research output: Contribution to journalArticle

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