Inclusion complex formation of steroidal drugs with hydroxypropyl-β-cyclodextrin studied by charge-transfer chromatography

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Abstract

The interaction between 17 steroidal drugs and hyroxypropyl-β-cyclodextrin (HPβBCD) was determined by charge-transfer chromatography and the relative strength of interaction was calculated. HPβCD interacted with each steroidal drugs decreasing the hydrophobicity of the guest molecules. The relative strength of interaction considerably depended on the structure of the drug molecule. Hydrophobicity parameters of drugs significantly influenced the strength of interaction indicating the involvement of hydrophobic forces in the binding of drugs to HPβCD. The marked influence of HPβCD on the hydrophobicity of drugs suggests that this interaction may modify the biological properties (adsorption, uptake, half-life etc.) of drug-HPβCD complexes drug resulting in modified efficacy. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume18
Issue number1-2
DOIs
Publication statusPublished - Oct 1 1998

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Keywords

  • Complex formation
  • Hydroxypropyl-β-cyclodextrin
  • Steroidal drugs

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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