Inclusion complex formation of antisense nucleotides with hydroxypropyl-β-cyclodextrin

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The interaction between 26 nucleoside derivatives and hyroxypropyl-β-cyclodextrin (HPBCD) was determined by charge-transfer chromatography. HPBCD interacted with each nucleoside decreasing the lipophilicity of the guest molecules. Both sterical (specific hydrophobic surface area) and hydrophobicity parameters of nucleosides influenced the strength of interaction. Substituents with longer alkyl chain considerably increased the strength of interaction whereas the effect of double or triple bond in the chain was negligible.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume141
Issue number1-2
DOIs
Publication statusPublished - Sep 6 1996

Fingerprint

Cyclodextrins
Nucleosides
Nucleotides
Hydrophobic and Hydrophilic Interactions
Chromatography

Keywords

  • Antisense nucleosides
  • Hydrophobic interaction
  • Hydroxypropyl-β-cyclodextrin

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Inclusion complex formation of antisense nucleotides with hydroxypropyl-β-cyclodextrin. / Cserháti, Tibor; Forgács, Esther; Szejtli, József.

In: International Journal of Pharmaceutics, Vol. 141, No. 1-2, 06.09.1996, p. 1-7.

Research output: Contribution to journalArticle

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