The relative frequency of leukemia in pediatric malignancies was 24.3% and its incidence was 39/100000 in 1994 in Hungary. The risk factors are well known, however, the etiology remains unknown in 90% of the cases. The determination of the morphological, histochemical, immunological and genetic characteristics of the leukemic cells in bone marrow is necessary for the therapy: this provides the basis of the optimal complex chemotherapy and of the decision whether bone marrow transplantation is necessary or not. Childhood leukemias are acute lymphoid in 80% in which a cure rate of 60-70% can be achieved, while in the acute myeloid type only 30-40%. The patients' quality of life having been cured from leukemia is sufficient in most cases and their offsprings are also healthy except some rare cases with hereditary disposition to leukemia. However, for some possible late sequelae (e.g. second malignancies), especially in high risk leukemia, the follow-up of these former patients is necessary.
|Number of pages||5|
|Journal||Lege Artis Medicinae|
|Publication status||Published - Mar 26 1996|
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