Incidence rates and disease course of paediatric inflammatory bowel diseases in Western Hungary between 1977 and 2011

Barbara D. Lovasz, L. Lakatos, Agnes Horvath, T. Pandúr, Z. Erdélyi, Mihaly Balogh, Istvan Szipocs, Zsuzsanna Vegh, G. Verès, Katalin E. Müller, Petra A. Golovics, Lajos S. Kiss, Michael D. Mandel, P. Lakatos

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Limited data are available on paediatric inflammatory bowel diseases in Eastern Europe. Our aim was to analyse disease characteristics in the population-based Veszprem province database between 1977 and 2011. Methods: 187 (10.5%, ulcerative colitis/Crohn's disease/undetermined colitis: 88/95/4) out of 1565 incident patients were diagnosed with a paediatric onset in this population-based prospective inception cohort. Results: The incidence of Crohn's disease and ulcerative colitis increased from 0 and 0.7 in 1977-1981 to 7.2 and 5.2 in 2007-2011 per 100,000 person years. Ileocolonic location (45%) and inflammatory disease behaviour (61%) were most frequent in Crohn's disease, while azathioprine use was frequent (66%) and surgical resection rates were high (33% at 5 years) in cases with paediatric onset. In ulcerative colitis, 34% of patients were diagnosed with extensive disease, with high rates of disease extension (26% and 41% at 5 and 10 years), fulminant episodes (19.3%) and systemic steroid use (52.3%). The cumulative rate of colectomy was low (6.9%). Conclusions: The incidence of paediatric inflammatory bowel diseases has rapidly increased in the last three decades in Western Hungary. Ileocolonic disease and a need for azathioprine were characteristic in paediatric Crohn's disease, while paediatric onset ulcerative colitis was characterised by extensive disease and disease extension, while the need for colectomy was low.

Original languageEnglish
Pages (from-to)405-411
Number of pages7
JournalDigestive and Liver Disease
Volume46
Issue number5
DOIs
Publication statusPublished - 2014

Fingerprint

Hungary
Inflammatory Bowel Diseases
Pediatrics
Incidence
Ulcerative Colitis
Crohn Disease
Colectomy
Azathioprine
Eastern Europe
Population Characteristics
Colitis
Steroids
Databases
Population

Keywords

  • Crohn's disease
  • Disease course
  • Disease phenotype
  • Incidence
  • Paediatric
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology
  • Medicine(all)

Cite this

Incidence rates and disease course of paediatric inflammatory bowel diseases in Western Hungary between 1977 and 2011. / Lovasz, Barbara D.; Lakatos, L.; Horvath, Agnes; Pandúr, T.; Erdélyi, Z.; Balogh, Mihaly; Szipocs, Istvan; Vegh, Zsuzsanna; Verès, G.; Müller, Katalin E.; Golovics, Petra A.; Kiss, Lajos S.; Mandel, Michael D.; Lakatos, P.

In: Digestive and Liver Disease, Vol. 46, No. 5, 2014, p. 405-411.

Research output: Contribution to journalArticle

Lovasz, Barbara D. ; Lakatos, L. ; Horvath, Agnes ; Pandúr, T. ; Erdélyi, Z. ; Balogh, Mihaly ; Szipocs, Istvan ; Vegh, Zsuzsanna ; Verès, G. ; Müller, Katalin E. ; Golovics, Petra A. ; Kiss, Lajos S. ; Mandel, Michael D. ; Lakatos, P. / Incidence rates and disease course of paediatric inflammatory bowel diseases in Western Hungary between 1977 and 2011. In: Digestive and Liver Disease. 2014 ; Vol. 46, No. 5. pp. 405-411.
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abstract = "Background: Limited data are available on paediatric inflammatory bowel diseases in Eastern Europe. Our aim was to analyse disease characteristics in the population-based Veszprem province database between 1977 and 2011. Methods: 187 (10.5{\%}, ulcerative colitis/Crohn's disease/undetermined colitis: 88/95/4) out of 1565 incident patients were diagnosed with a paediatric onset in this population-based prospective inception cohort. Results: The incidence of Crohn's disease and ulcerative colitis increased from 0 and 0.7 in 1977-1981 to 7.2 and 5.2 in 2007-2011 per 100,000 person years. Ileocolonic location (45{\%}) and inflammatory disease behaviour (61{\%}) were most frequent in Crohn's disease, while azathioprine use was frequent (66{\%}) and surgical resection rates were high (33{\%} at 5 years) in cases with paediatric onset. In ulcerative colitis, 34{\%} of patients were diagnosed with extensive disease, with high rates of disease extension (26{\%} and 41{\%} at 5 and 10 years), fulminant episodes (19.3{\%}) and systemic steroid use (52.3{\%}). The cumulative rate of colectomy was low (6.9{\%}). Conclusions: The incidence of paediatric inflammatory bowel diseases has rapidly increased in the last three decades in Western Hungary. Ileocolonic disease and a need for azathioprine were characteristic in paediatric Crohn's disease, while paediatric onset ulcerative colitis was characterised by extensive disease and disease extension, while the need for colectomy was low.",
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T1 - Incidence rates and disease course of paediatric inflammatory bowel diseases in Western Hungary between 1977 and 2011

AU - Lovasz, Barbara D.

AU - Lakatos, L.

AU - Horvath, Agnes

AU - Pandúr, T.

AU - Erdélyi, Z.

AU - Balogh, Mihaly

AU - Szipocs, Istvan

AU - Vegh, Zsuzsanna

AU - Verès, G.

AU - Müller, Katalin E.

AU - Golovics, Petra A.

AU - Kiss, Lajos S.

AU - Mandel, Michael D.

AU - Lakatos, P.

PY - 2014

Y1 - 2014

N2 - Background: Limited data are available on paediatric inflammatory bowel diseases in Eastern Europe. Our aim was to analyse disease characteristics in the population-based Veszprem province database between 1977 and 2011. Methods: 187 (10.5%, ulcerative colitis/Crohn's disease/undetermined colitis: 88/95/4) out of 1565 incident patients were diagnosed with a paediatric onset in this population-based prospective inception cohort. Results: The incidence of Crohn's disease and ulcerative colitis increased from 0 and 0.7 in 1977-1981 to 7.2 and 5.2 in 2007-2011 per 100,000 person years. Ileocolonic location (45%) and inflammatory disease behaviour (61%) were most frequent in Crohn's disease, while azathioprine use was frequent (66%) and surgical resection rates were high (33% at 5 years) in cases with paediatric onset. In ulcerative colitis, 34% of patients were diagnosed with extensive disease, with high rates of disease extension (26% and 41% at 5 and 10 years), fulminant episodes (19.3%) and systemic steroid use (52.3%). The cumulative rate of colectomy was low (6.9%). Conclusions: The incidence of paediatric inflammatory bowel diseases has rapidly increased in the last three decades in Western Hungary. Ileocolonic disease and a need for azathioprine were characteristic in paediatric Crohn's disease, while paediatric onset ulcerative colitis was characterised by extensive disease and disease extension, while the need for colectomy was low.

AB - Background: Limited data are available on paediatric inflammatory bowel diseases in Eastern Europe. Our aim was to analyse disease characteristics in the population-based Veszprem province database between 1977 and 2011. Methods: 187 (10.5%, ulcerative colitis/Crohn's disease/undetermined colitis: 88/95/4) out of 1565 incident patients were diagnosed with a paediatric onset in this population-based prospective inception cohort. Results: The incidence of Crohn's disease and ulcerative colitis increased from 0 and 0.7 in 1977-1981 to 7.2 and 5.2 in 2007-2011 per 100,000 person years. Ileocolonic location (45%) and inflammatory disease behaviour (61%) were most frequent in Crohn's disease, while azathioprine use was frequent (66%) and surgical resection rates were high (33% at 5 years) in cases with paediatric onset. In ulcerative colitis, 34% of patients were diagnosed with extensive disease, with high rates of disease extension (26% and 41% at 5 and 10 years), fulminant episodes (19.3%) and systemic steroid use (52.3%). The cumulative rate of colectomy was low (6.9%). Conclusions: The incidence of paediatric inflammatory bowel diseases has rapidly increased in the last three decades in Western Hungary. Ileocolonic disease and a need for azathioprine were characteristic in paediatric Crohn's disease, while paediatric onset ulcerative colitis was characterised by extensive disease and disease extension, while the need for colectomy was low.

KW - Crohn's disease

KW - Disease course

KW - Disease phenotype

KW - Incidence

KW - Paediatric

KW - Ulcerative colitis

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DO - 10.1016/j.dld.2013.12.013

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VL - 46

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JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

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