Valvulopathia elôfordulása tartósan komplett remisszióban lévô Hodgkin-kóros betegeknél.

Translated title of the contribution: Incidence of valvulopathy in Hodgkin-disease patients in long-term complete remission

Judit Végh, Györgyi Vadász, Zsófia Miltényi, Pál Soltész, Franciska Tizedes, Arpád Illés

Research output: Contribution to journalArticle

Abstract

AIM: To study the occurrence of valvulopathies after treatment in Hodgkin's disease patients. PATIENTS AND METHODS: 124 Hodgkin's disease patients in complete remission for at least 1 year were echocardiographically examined. RESULTS: Abnormal finding was observed in 48/124 (38.4%) of patients, all of them presented with regurgitation, no stenosis was observed. Regurgitation of grade I or II was recorded in most cases. We have found single valvulopathy in 25/48 (52.1%) of patients, and multiple valvulopathy in 23/48 (47.9%) of patients. In most cases (78.7%) the valvulopathy was detected in left heart. Among these 48 patients the ratio of females was significantly higher than those of males, and also the ratio of the patients in early phase compared with those in late phase. We could detect vitium mostly in those patients who had mediastinal irradiation. The combined treatment, including anthracycline therapy, did not increase the frequency of vitium. CONCLUSION: The occurrence of valvulopathy is frequent in Hodgkin's disease patients, particularly in patients treated by radiation. This is the reason why Hodgkin's disease patients should be examined regularly with echocardiography. These patients with valvulopathy need treatment adjusted to their state of health, and where possible, the complications should be prevented. In the future, when planning of the radiotherapy mediastinal irradiation of the Hodgkin's disease patients their heart protection from radiation should be taken into account.

Original languageHungarian
Pages (from-to)357-360
Number of pages4
JournalMagyar Onkologia
Volume46
Issue number4
Publication statusPublished - 2002

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Hodgkin Disease
Incidence
Radiation Protection
Anthracyclines
Therapeutics
Echocardiography
Pathologic Constriction
Radiotherapy
Radiation

ASJC Scopus subject areas

  • Cancer Research

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Valvulopathia elôfordulása tartósan komplett remisszióban lévô Hodgkin-kóros betegeknél. / Végh, Judit; Vadász, Györgyi; Miltényi, Zsófia; Soltész, Pál; Tizedes, Franciska; Illés, Arpád.

In: Magyar Onkologia, Vol. 46, No. 4, 2002, p. 357-360.

Research output: Contribution to journalArticle

Végh, Judit ; Vadász, Györgyi ; Miltényi, Zsófia ; Soltész, Pál ; Tizedes, Franciska ; Illés, Arpád. / Valvulopathia elôfordulása tartósan komplett remisszióban lévô Hodgkin-kóros betegeknél. In: Magyar Onkologia. 2002 ; Vol. 46, No. 4. pp. 357-360.
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abstract = "AIM: To study the occurrence of valvulopathies after treatment in Hodgkin's disease patients. PATIENTS AND METHODS: 124 Hodgkin's disease patients in complete remission for at least 1 year were echocardiographically examined. RESULTS: Abnormal finding was observed in 48/124 (38.4{\%}) of patients, all of them presented with regurgitation, no stenosis was observed. Regurgitation of grade I or II was recorded in most cases. We have found single valvulopathy in 25/48 (52.1{\%}) of patients, and multiple valvulopathy in 23/48 (47.9{\%}) of patients. In most cases (78.7{\%}) the valvulopathy was detected in left heart. Among these 48 patients the ratio of females was significantly higher than those of males, and also the ratio of the patients in early phase compared with those in late phase. We could detect vitium mostly in those patients who had mediastinal irradiation. The combined treatment, including anthracycline therapy, did not increase the frequency of vitium. CONCLUSION: The occurrence of valvulopathy is frequent in Hodgkin's disease patients, particularly in patients treated by radiation. This is the reason why Hodgkin's disease patients should be examined regularly with echocardiography. These patients with valvulopathy need treatment adjusted to their state of health, and where possible, the complications should be prevented. In the future, when planning of the radiotherapy mediastinal irradiation of the Hodgkin's disease patients their heart protection from radiation should be taken into account.",
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