A thrombophilia elofordulása és a veseerek thrombosisának veszélye veseátültetett betegeknél.

Translated title of the contribution: [Incidence of thrombophilia and risk of renal vessel thrombosis in kidney transplant recipients].

Eva Toronyi, Zsolt Máthé, Rita Chmel, Marina Varga, Veronika Kozma, Roland Trent, Gellért Tozsér, Gergely Nagy, Róbert Langer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Kidney transplantation is the optimal treatment of end stage kidney disease. The most common vascular complication in the early postoperative period is thrombosis of the renal artery and vein. These complications usually lead to the loss of the transplanted kidney. of our study was to identify those factors which represent an increased risk for thrombotic complication and determine whether routine screening for thrombophilia is justifiable before transplantation. As an illustration to this problem we report a case of successful renal vein recanalisation after thrombosis. We give an overview of the literature about incidence of renal graft thrombosis, hypercoagulable states, predictive value of factor V. Leiden and prothrombin G20210A mutations in venous thromboembolism. We discuss those publications that suggest a preoperative screening of transplant candidates for hypercoagulable states and thrombophilia and those that do not think that such screening is reasonable. In our case a 28 year old male patient received a cadaveric kidney. Thrombosis of the renal vein was diagnosed 8 hours after transplantation. Reoperation was performed immediately: venous anastomosis was opened, the thrombus removed. After reoperation the circulation of the kidney recovered, intravenous heparin treatment was introduced immediately. Results: 24 months later the kidney is still functioning well. Postoperative thrombophilia screening showed heterozygosity for factor V Leiden. There are only few publications reporting on successful recanalisation after renal vein thrombosis. In our case rapid diagnosis and immediate operative treatment saved the graft. There is no uniform proposal in the literature whether preoperative screening for thrombophilia is justifiable or not. In our view screening for thrombophilia and thromboprophylaxis is mandatory. Extensive prospective studies should be undertaken to refine the risks and establish the associations of thrombophilia and thromboembolism after kidney transplantation.

Original languageHungarian
Pages (from-to)229-234
Number of pages6
JournalMagyar sebészet
Volume64
Issue number5
Publication statusPublished - Oct 2011

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Thrombophilia
Thrombosis
Renal Veins
Kidney
Incidence
Transplants
Reoperation
Kidney Transplantation
Publications
Transplantation
Renal Circulation
Thromboembolism
Venous Thromboembolism
Prothrombin
Renal Artery
Postoperative Period
Chronic Kidney Failure
Blood Vessels
Heparin
Transplant Recipients

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Toronyi, E., Máthé, Z., Chmel, R., Varga, M., Kozma, V., Trent, R., ... Langer, R. (2011). A thrombophilia elofordulása és a veseerek thrombosisának veszélye veseátültetett betegeknél. Magyar sebészet, 64(5), 229-234.

A thrombophilia elofordulása és a veseerek thrombosisának veszélye veseátültetett betegeknél. / Toronyi, Eva; Máthé, Zsolt; Chmel, Rita; Varga, Marina; Kozma, Veronika; Trent, Roland; Tozsér, Gellért; Nagy, Gergely; Langer, Róbert.

In: Magyar sebészet, Vol. 64, No. 5, 10.2011, p. 229-234.

Research output: Contribution to journalArticle

Toronyi, E, Máthé, Z, Chmel, R, Varga, M, Kozma, V, Trent, R, Tozsér, G, Nagy, G & Langer, R 2011, 'A thrombophilia elofordulása és a veseerek thrombosisának veszélye veseátültetett betegeknél.', Magyar sebészet, vol. 64, no. 5, pp. 229-234.
Toronyi E, Máthé Z, Chmel R, Varga M, Kozma V, Trent R et al. A thrombophilia elofordulása és a veseerek thrombosisának veszélye veseátültetett betegeknél. Magyar sebészet. 2011 Oct;64(5):229-234.
Toronyi, Eva ; Máthé, Zsolt ; Chmel, Rita ; Varga, Marina ; Kozma, Veronika ; Trent, Roland ; Tozsér, Gellért ; Nagy, Gergely ; Langer, Róbert. / A thrombophilia elofordulása és a veseerek thrombosisának veszélye veseátültetett betegeknél. In: Magyar sebészet. 2011 ; Vol. 64, No. 5. pp. 229-234.
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