Veleszületett rekeszsérvhez társult rendellenessé gek megoszlása klinikánk 15 éves anyagában

Translated title of the contribution: Incidence of congenital diaphragmatic hernia with associated malformations in the last 15 years in a tertiary referral institute

Ágnes Harmath, Júlia Hajdú, Barbara Pete, Ákos Csaba, Éva Görbe, Anna Beke, Zoltán Papp

Research output: Contribution to journalArticle

Abstract

The authors analysed the data on congenital diaphragmatic hernia cases with associated malformations from the records of the 1st Department of Obstetrics and Gynecology, Semmelweis University Faculty of Medicine, Budapest, between 1st July, 1990 and 30th June, 2005. The studied period was analyzed in two parts. The pre- and postnatal examinations verified congenital diaphragmatic hernia in 100 cases. Associated malformations were diagnosed in 71 cases. The incidence of associated malformations was 73.9% (34/46 cases) during the first, and 68.5% (37/54 cases) during the second study period. In 37 cases the congenital diaphragmatic hernia was diagnosed before the 24th gestational week. The rate of early diagnosed cases was doubled during the second period. In 7 of the 71 associated malformation cases the congenital diaphragmatic hernia was diagnosed only postnatally. The hernia was left-sided in 56, right-sided in 9 and both-sided in 6 cases. The incidence of right sided hernia was three times higher between 1998 and 2005. Most frequently cardiovascular and pulmonary anomalies were associated. The number of these associations doubled in the second period. Between 1990 and 1997 the conotruncal malformations, while between 1998 and 2005 the complex malformations occurred in higher number. Regarding pulmonary malformations the number of hypoplasia cases have increased. Polyhydramnios was observed in 20 associated malformation cases. In four cases a chromosomal anomaly (trisomy-18 in three, trisomy-21 in one case) was diagnosed. Pregnancy was terminated in 34 cases. From the 30 newborns 4 have survived. Intrauterine or intrapartum death occurred in 5 cases. We have no data regarding the outcome of pregnancy in two cases. According to the analysis of the 15-years' data doubling in the incidence of cardiovascular, pulmonary and craniofacial anomalies was observed, while the incidence of central nervous system malformations decreased. Improvement in the technical facilities and experience give the possibility of diagnosing higher number of associated malformations prior to the 24th gestational week. In these cases parents can decide and choose on terminating the pregnancy.

Translated title of the contributionIncidence of congenital diaphragmatic hernia with associated malformations in the last 15 years in a tertiary referral institute
Original languageHungarian
Pages (from-to)397-404
Number of pages8
JournalMagyar Noorvosok Lapja
Volume69
Issue number5
Publication statusPublished - Nov 17 2006

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Fingerprint Dive into the research topics of 'Incidence of congenital diaphragmatic hernia with associated malformations in the last 15 years in a tertiary referral institute'. Together they form a unique fingerprint.

  • Cite this