Incidence and risk factors of prosthetic valve endocarditis

A. Árvay, M. Lengyel

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To study the incidence and risk factors of prosthetic valve endocarditis (PVE) we followed 99,5% of 912 patients who had valve replacements from 1 January 1981 to 31 December 1985 for 1-6 (mean 3) years. PVE occurred in 27 patients (2.96% or 0.98% per patient-year). The incidence of PVE in the aortic position (3.9%) was significantly higher than in the mitral position (1.5%): chisquare = 6.1, P < 0.025. PVE developed in 19 of 329 patients with bioprostheses (5.8%), and in 8 of 583 patients with mechanical valves (1.4%): chisquare = 14.48, P < 0.005). Actuarially at 5-year follow-up, 90.7% ± 2.16% of the bioprosthetic group and 98.4% ± 0.56% of the mechanical valve group was free of PVE (P < 0.001). Antecedent endocarditis increased both the incidence and relative risk of PVE 7-fold compared to patients without antecedent endocarditis (chi-square = 32.0, P < 0.0001). Bioprosthetic valve replacement in infective endocarditis increased the risk of PVE 12-fold compared to valve replacement by mechanical prostheses. In conclusion: in the order of importance, antecedent endocarditis, bioprostheses and aortic position are risk factors in the development of PVE. Bioprostheses implanted in patients with antecedent endocarditis further enhance the risk of PVE.

Original languageEnglish
Pages (from-to)336,337-339
JournalEuropean Journal of Cardio-Thoracic Surgery
Issue number5
Publication statusPublished - Dec 1 1988



  • Bioprosthetic valve
  • Mechanical valve prosthesis
  • Native valve endocarditis
  • Prosthetic valve endocarditis
  • Valve replacement

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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