Incidence and outcome of congenital cytomegalovirus infection in selected groups of preterm and full-term neonates under intensive care

Aranka Nagy, E. Endreffy, Károly Streitman, S. Pintér, Rozália Pusztai

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Congenital cytomegalovirus (CMV) infection is the leading cause of mental retardation and hearing impairment. Examination for the presence of CMV infection was carried out in a selected population of 70 neonates. Urine samples were tested for CMV by means of a nested polymerase chain reaction. CMV was detected in 6 (16.7%) of the 36 preterm newborns and in 5 (14.7%) of the 34 full-term newborns. One preterm neonate died and the remaining 10 newborns were followed up. Two children born at full-term did not excrete CMV at 2 years of age and were symptom-free. Of 8 CMV-excreting children (5 preterm and 3 full-term), 2 were symptom-free (1 preterm and 1 term). Symptomatic CMV disease developed in 6 children (4 preterm and 2 full-term), with mental retardation (n=4), hearing loss (n=1), strabismus (n=2) or bronchial asthma (n=1). Screening of such neonates is important; those identified as congenitally CMV-infected can be monitored to correct any sequelae immediately.

Original languageEnglish
Pages (from-to)819-824
Number of pages6
JournalIn Vivo
Volume18
Issue number6
Publication statusPublished - Nov 2004

Fingerprint

Cytomegalovirus Infections
Audition
Critical Care
Cytomegalovirus
Newborn Infant
Polymerase chain reaction
Incidence
Screening
Hearing Loss
Intellectual Disability
Strabismus
Asthma
Urine
Polymerase Chain Reaction
Population

Keywords

  • Congenital infection
  • Cytomegalovirus
  • Full-term neonates
  • Intensive care
  • Preterm neonates

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Incidence and outcome of congenital cytomegalovirus infection in selected groups of preterm and full-term neonates under intensive care. / Nagy, Aranka; Endreffy, E.; Streitman, Károly; Pintér, S.; Pusztai, Rozália.

In: In Vivo, Vol. 18, No. 6, 11.2004, p. 819-824.

Research output: Contribution to journalArticle

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