Incidence and associations of single umbilical artery in prenatally diagnosed malformed, midtrimester fetuses: A review of 62 cases

K. Csecsei, T. Kovacs, S. A. Hinchliffe, Z. Papp

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The absence of one umbilical artery (SUA) is the most common malformation of the umbilical cord. It may accompany other abnormalities or occur as an isolated defect. We examined 885 fetuses, terminated following the prenatal diagnosis of serious or lethal malformations between April 1977 and March 1989, for the presence of SUA. We found 62 cases of SUA. This represents an incidence of 7.01% (62/885). The most common abnormalities found in association with SUA were: (1) multiple malformations (8/11 cases, SUA incidence = 72.7%), (2) ADAM complex (7/14 cases, SUA incidence = 50.%), (3) multicystic renal dysplasia (5/20 cases, SUA incidence = 25.%), and (4) Potter sequence (5/21 cases, SUA incidence = 23.8%). These associations have not been documented previously. In 6 fetuses the Meckel syndrome was diagnosed, and SUA was present in 2 of these. Therefore, SUA may represent an additional anomaly in Meckel syndrome that has not been reported previously.

Original languageEnglish
Pages (from-to)524-530
Number of pages7
JournalAmerican Journal of Medical Genetics
Volume43
Issue number3
DOIs
Publication statusPublished - 1992

Fingerprint

Single Umbilical Artery
Second Pregnancy Trimester
Fetus
Incidence
Multicystic Dysplastic Kidney
Umbilical Arteries
Umbilical Cord
Prenatal Diagnosis

Keywords

  • association
  • fetus
  • malformation
  • pathology
  • prenatal diagnosis
  • single umbilical artery

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Incidence and associations of single umbilical artery in prenatally diagnosed malformed, midtrimester fetuses : A review of 62 cases. / Csecsei, K.; Kovacs, T.; Hinchliffe, S. A.; Papp, Z.

In: American Journal of Medical Genetics, Vol. 43, No. 3, 1992, p. 524-530.

Research output: Contribution to journalArticle

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