Inactivation of α and β thrombin by antithrombin III and heparin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The inactivation of α and β thrombin by antithrombin III and heparin was studied, since it had been suggested that two forms of thrombin exist with respect to heparin sensitivity (Machovich 1975b). It was found that the inactivation rates of α and β thrombin by antithrombin were different, namely α thrombin was more sensitive to antithrombin than β thrombin. Heparin facilitated the complex formation between α thrombin and antithrombin III, whereas β thrombin inactivation was only slightly affected. Furthermore, heparin protected α thrombin against the inactivating effect of heat, while β thrombin lost its activity during the heat treatment. These findings suggest that the formation of β thrombin in blood circulation may have an important role in thrombosis predisposition.

Original languageEnglish
Pages (from-to)503-508
Number of pages6
JournalThrombosis and Haemostasis
Volume36
Issue number3
Publication statusPublished - Dec 1 1976

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Inactivation of α and β thrombin by antithrombin III and heparin'. Together they form a unique fingerprint.

  • Cite this