In vztro scavenger effect of dihydroquinoline type derivatives in different free radical generating systems

A. Blázovics, I. György, A. J.N. Zsinka, P. Biacs, G. Földiák, J. Feher

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Abstract

The non-toxic and water soluble dihydroquinoline type antioxidants: CH 402 (Na-2,2-dimethyl-l.2-dihydroquinoline-4-yl methane sulphonate) and MTDQ-DA (6.6-methylene bis 2.2-dimethyl-4-methane sulphonicacid: Na-1.2-dihydroquinoline) were studied in various in vitro tests in which oxygen free radicals were generated. Both compounds were shown to scavenge superoxide radical anions O-2 produced in aqueous solution by pulse radiolysis with rate constants k (O-2 + MTDQ-DA) = 4.108dm3 mol-1s-1 and k(O-2 +CH402) = 1.5.107dm3 mol-1s -1. CH 402 and MTDQ-DA reduced the H2O2 produced in the glucose-glucose oxidase reaction, which was detected by the luminol + hemin reaction with a chemilumi-nometric method. The dihydroquinoline type substrates inhibited the NADPH-induced and Fe3 +-stimulated lipid peroxidation and the ascorbic acid-induced non-enzymatic peroxidation pathways in microsomal fractions of rat and mouse liver.

Original languageEnglish
Pages (from-to)217-226
Number of pages10
JournalFree radical research
Volume6
Issue number4
DOIs
Publication statusPublished - Jan 1 1989

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Keywords

  • Dihydroquinoline type antioxidants
  • Free radicals
  • Lipid peroxidation
  • Pulse radiolysis

ASJC Scopus subject areas

  • Biochemistry

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