The non-toxic and water soluble dihydroquinoline type antioxidants: CH 402 (Na-2,2-dimethyl-l.2-dihydroquinoline-4-yl methane sulphonate) and MTDQ-DA (6.6-methylene bis 2.2-dimethyl-4-methane sulphonicacid: Na-1.2-dihydroquinoline) were studied in various in vitro tests in which oxygen free radicals were generated. Both compounds were shown to scavenge superoxide radical anions O-2 produced in aqueous solution by pulse radiolysis with rate constants k (O-2 + MTDQ-DA) = 4.108dm3 mol-1s-1 and k(O-2 +CH402) = 1.5.107dm3 mol-1s -1. CH 402 and MTDQ-DA reduced the H2O2 produced in the glucose-glucose oxidase reaction, which was detected by the luminol + hemin reaction with a chemilumi-nometric method. The dihydroquinoline type substrates inhibited the NADPH-induced and Fe3 +-stimulated lipid peroxidation and the ascorbic acid-induced non-enzymatic peroxidation pathways in microsomal fractions of rat and mouse liver.
- Dihydroquinoline type antioxidants
- Free radicals
- Lipid peroxidation
- Pulse radiolysis
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