The aim of our work was to develop a transgenic animal model with decreased neuropeptide levels in the brain for studying the in vivo effects of potential prolyl oligopeptodase (PO) inhibitors on impaired memory functions. For this purpose, we generated transgenic mice that carry the human PO "mini-gene" under the control of the platelet-derived growth factor β promoter (PDGFβ). Four transgenic lines were derived and the brain specific expression of human PO transcript was examined by RT-PCR analysis. Preliminary data showed the presence of human PO mRNA in the brain of one of the four lines.
|Number of pages||4|
|Journal||Archiv fur Tierzucht|
|Publication status||Published - Dec 1 1999|
ASJC Scopus subject areas
- Food Animals
- Animal Science and Zoology