In vivo testing of potential anti-amnesic therapeutic agents by transgenic animal model

Ákos Gerencsér, L. Hiripi, F. Makovics, S. Tóth, G. Szabó, Z. Bosze, P. Arányi

Research output: Contribution to journalArticle

Abstract

The aim of our work was to develop a transgenic animal model with decreased neuropeptide levels in the brain for studying the in vivo effects of potential prolyl oligopeptodase (PO) inhibitors on impaired memory functions. For this purpose, we generated transgenic mice that carry the human PO "mini-gene" under the control of the platelet-derived growth factor β promoter (PDGFβ). Four transgenic lines were derived and the brain specific expression of human PO transcript was examined by RT-PCR analysis. Preliminary data showed the presence of human PO mRNA in the brain of one of the four lines.

Original languageEnglish
Pages (from-to)156-159
Number of pages4
JournalArchiv fur Tierzucht
Volume42
Publication statusPublished - Dec 1 1999

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology

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    Gerencsér, Á., Hiripi, L., Makovics, F., Tóth, S., Szabó, G., Bosze, Z., & Arányi, P. (1999). In vivo testing of potential anti-amnesic therapeutic agents by transgenic animal model. Archiv fur Tierzucht, 42, 156-159.